A sulfilimine bond identified in collagen IV. Vanacore R, Ham AJ, Voehler M, Sanders CR, Conrads TP, Veenstra TD, Sharpless KB, Dawson PE, Hudson BG (2009) Science 325: 1230-4 Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner. Woo KV, Qu X, Babaev VR, Linton MF, Guzman RJ, Fazio S, Baldwin HS (2011) J Clin Invest 121: 1624-35 Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Pimentel DR, Amin JK, Xiao L, Miller T, Viereck J, Oliver-Krasinski J, Baliga R, Wang J, Siwik DA, Singh K, Pagano P, Colucci WS, Sawyer DB (2001) Circ Res 89: 453-60 Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase. Sorescu GP, Song H, Tressel SL, Hwang J, Dikalov S, Smith DA, Boyd NL, Platt MO, Lassègue B, Griendling KK, Jo H (2004) Circ Res 95: 773-9 Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase. Wu J, Thabet SR, Kirabo A, Trott DW, Saleh MA, Xiao L, Madhur MS, Chen W, Harrison DG (2014) Circ Res 114: 616-25 GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide. Li L, Rezvan A, Salerno JC, Husain A, Kwon K, Jo H, Harrison DG, Chen W (2010) Circ Res 106: 328-36 Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. Beningo KA, Dembo M, Kaverina I, Small JV, Wang YL (2001) J Cell Biol 153: 881-8 Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb-IIIa. Peterson DM, Stathopoulos NA, Giorgio TD, Hellums JD, Moake JL (1987) Blood 69: 625-8 Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates. Guelcher SA, Srinivasan A, Dumas JE, Didier JE, McBride S, Hollinger JO (2008) Biomaterials 29: 1762-75 Tissue-to-cellular level deformation coupling in cell micro-integrated elastomeric scaffolds. Stella JA, Liao J, Hong Y, David Merryman W, Wagner WR, Sacks MS (2008) Biomaterials 29: 3228-36 Redox signaling in an in vivo murine model of low magnitude oscillatory wall shear stress. Willett NJ, Kundu K, Knight SF, Dikalov S, Murthy N, Taylor WR (2011) Antioxid Redox Signal 15: 1369-78 Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts. Hutcheson JD, Chen J, Sewell-Loftin MK, Ryzhova LM, Fisher CI, Su YR, Merryman WD (2013) Arterioscler Thromb Vasc Biol 33: 114-20 Structural and functional characterization of pi bulges and other short intrahelical deformations. Cartailler JP, Luecke H (2004) Structure 12: 133-44 Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide. Loperena R, Van Beusecum JP, Itani HA, Engel N, Laroumanie F, Xiao L, Elijovich F, Laffer CL, Gnecco JS, Noonan J, Maffia P, Jasiewicz-Honkisz B, Czesnikiewicz-Guzik M, Mikolajczyk T, Sliwa T, Dikalov S, Weyand CM, Guzik TJ, Harrison DG (2018) Cardiovasc Res 114: 1547-1563 Tensile stress stimulates microtubule outgrowth in living cells. Kaverina I, Krylyshkina O, Beningo K, Anderson K, Wang YL, Small JV (2002) J Cell Sci 115: 2283-91 Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape. Sims JR, Karp S, Ingber DE (1992) J Cell Sci 103 ( Pt 4): 1215-22 Important role for AMPKalpha1 in limiting skeletal muscle cell hypertrophy. Mounier R, Lantier L, Leclerc J, Sotiropoulos A, Pende M, Daegelen D, Sakamoto K, Foretz M, Viollet B (2009) FASEB J 23: 2264-73 Cellularized cylindrical fiber/hydrogel composites for ligament tissue engineering. Thayer PS, Dimling AF, Plessl DS, Hahn MR, Guelcher SA, Dahlgren LA, Goldstein AS (2014) Biomacromolecules 15: 75-83 Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility. Huke S, Knollmann BC (2010) J Mol Cell Cardiol 48: 824-33 Cellular traction stresses mediate extracellular matrix degradation by invadopodia. Jerrell RJ, Parekh A (2014) Acta Biomater 10: 1886-96 Activation of the TRPV1 cation channel contributes to stress-induced astrocyte migration. Ho KW, Lambert WS, Calkins DJ (2014) Glia 62: 1435-51 Activation of S6 kinase by repeated cycles of stretching and relaxation in rat glomerular mesangial cells. Evidence for involvement of protein kinase C. Homma T, Akai Y, Burns KD, Harris RC (1992) J Biol Chem 267: 23129-35 Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion. Hwang J, Saha A, Boo YC, Sorescu GP, McNally JS, Holland SM, Dikalov S, Giddens DP, Griendling KK, Harrison DG, Jo H (2003) J Biol Chem 278: 47291-8 A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells. Khandelwal P, Prakasam HS, Clayton DR, Ruiz WG, Gallo LI, van Roekel D, Lukianov S, Peränen J, Goldenring JR, Apodaca G (2013) Mol Biol Cell 24: 1007-19 Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction. Pyle AL, Atkinson JB, Pozzi A, Reese J, Eckes B, Davidson JM, Crimmins DL, Young PP (2008) Am J Pathol 173: 1577-88 Knee joint loading in knee osteoarthritis: influence of abdominal and thigh fat. Messier SP, Beavers DP, Loeser RF, Carr JJ, Khajanchi S, Legault C, Nicklas BJ, Hunter DJ, Devita P (2014) Med Sci Sports Exerc 46: 1677-83 Shear-induced platelet activation measured by flow cytometry. Purvis NB, Giorgio TD, Stelzer GT, Shults KE (1994) Ann N Y Acad Sci 714: 309-11 Convective flow increases lipoplex delivery rate to in vitro cellular monolayers. Harris SS, Giorgio TD (2005) Gene Ther 12: 512-20 Changes in skeletal collagen cross-links and matrix hydration in high- and low-turnover chronic kidney disease. Allen MR, Newman CL, Chen N, Granke M, Nyman JS, Moe SM (2015) Osteoporos Int 26: 977-85 A method to track cortical surface deformations using a laser range scanner. Sinha TK, Dawant BM, Duay V, Cash DM, Weil RJ, Thompson RC, Weaver KD, Miga MI (2005) IEEE Trans Med Imaging 24: 767-81 Continuous stretch-relaxation in culture alters rat mesangial cell morphology, growth characteristics, and metabolic activity. Harris RC, Haralson MA, Badr KF (1992) Lab Invest 66: 548-54 Non-invasive predictors of human cortical bone mechanical properties: T(2)-discriminated H NMR compared with high resolution X-ray. Horch RA, Gochberg DF, Nyman JS, Does MD (2011) PLoS One 6: e16359 A three-dimensional computational model of collagen network mechanics. Lee B, Zhou X, Riching K, Eliceiri KW, Keely PJ, Guelcher SA, Weaver AM, Jiang Y (2014) PLoS One 9: e111896 Molecular beacons can assess changes in expression and 3'-polyadenylation of human eNOS mRNA. Jones R, Baker MB, Weber M, Harrison DG, Bao G, Searles CD (2009) Am J Physiol Cell Physiol 296: C498-504 Cyclic strain and motion control produce opposite oxidative responses in two human endothelial cell types. Sung HJ, Yee A, Eskin SG, McIntire LV (2007) Am J Physiol Cell Physiol 293: C87-94 Molecular force balance measurements reveal that double-stranded DNA unbinds under force in rate-dependent pathways. Albrecht CH, Neuert G, Lugmaier RA, Gaub HE (2008) Biophys J 94: 4766-74 Upregulation of forces and morphogenic asymmetries in dorsal closure during Drosophila development. Peralta XG, Toyama Y, Hutson MS, Montague R, Venakides S, Kiehart DP, Edwards GS (2007) Biophys J 92: 2583-96 Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress. McNally JS, Davis ME, Giddens DP, Saha A, Hwang J, Dikalov S, Jo H, Harrison DG (2003) Am J Physiol Heart Circ Physiol 285: H2290-7 Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis. Merryman WD, Youn I, Lukoff HD, Krueger PM, Guilak F, Hopkins RA, Sacks MS (2006) Am J Physiol Heart Circ Physiol 290: H224-31 Structural and functional characterization of the monomeric U-box domain from E4B. Nordquist KA, Dimitrova YN, Brzovic PS, Ridenour WB, Munro KA, Soss SE, Caprioli RM, Klevit RE, Chazin WJ (2010) Biochemistry 49: 347-55
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.