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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to Adipocytes are shown below. Double-click or tap a node for more information.
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- The natriuretic peptides and fat metabolism.
Wang TJ
(2012) N Engl J Med 367: 377-8 - Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.
Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS
(2007) Nature 447: 959-65 - Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation.
Omatsu Y, Seike M, Sugiyama T, Kume T, Nagasawa T
(2014) Nature 508: 536-40 - Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.
Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW, Lange LA, Liu X, Lohman K, Lu L, Mahajan A, O'Connell JR, Parihar A, Peralta JM, Smith AV, Zhang Y, Homuth G, Kissebah AH, Kullberg J, Laqua R, Launer LJ, Nauck M, Olivier M, Peyser PA, Terry JG, Wojczynski MK, Yao J, Bielak LF, Blangero J, Borecki IB, Bowden DW, Carr JJ, Czerwinski SA, Ding J, Friedrich N, Gudnason V, Harris TB, Ingelsson E, Johnson AD, Kardia SL, Langefeld CD, Lind L, Liu Y, Mitchell BD, Morris AP, Mosley TH, Rotter JI, Shuldiner AR, Towne B, Völzke H, Wallaschofski H, Wilson JG, Allison M, Lindgren CM, Goessling W, Cupples LA, Steinhauser ML, Fox CS
(2017) Nat Genet 49: 125-130 - Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM
(2014) Cell 156: 304-16 - The protein kinase IKKepsilon regulates energy balance in obese mice.
Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR
(2009) Cell 138: 961-75 - Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.
Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF
(2001) Nat Med 7: 699-705 - β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.
Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE
(2014) Cell Metab 19: 96-108 - Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.
Chen S, Wasserman DH, MacKintosh C, Sakamoto K
(2011) Cell Metab 13: 68-79 - Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells.
Crossno JT, Majka SM, Grazia T, Gill RG, Klemm DJ
(2006) J Clin Invest 116: 3220-8 - IRF3 promotes adipose inflammation and insulin resistance and represses browning.
Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, Tenen D, Roh HC, Kong X, Kazak L, Ahmad R, Rosen ED
(2016) J Clin Invest 126: 2839-54 - Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling.
Boucher J, Mori MA, Lee KY, Smyth G, Liew CW, Macotela Y, Rourk M, Bluher M, Russell SJ, Kahn CR
(2012) Nat Commun 3: 902 - HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.
Ferrari A, Longo R, Fiorino E, Silva R, Mitro N, Cermenati G, Gilardi F, Desvergne B, Andolfo A, Magagnotti C, Caruso D, Fabiani E, Hiebert SW, Crestani M
(2017) Nat Commun 8: 93 - Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.
Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB, GoT2D Consortium, NHGRI JHS/FHS Allelic Spectrum Project, SIGMA T2D Consortium, T2D-GENES Consortium, Rosen ED, Altshuler D
(2014) Proc Natl Acad Sci U S A 111: 13127-32 - Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes.
Imai T, Jiang M, Chambon P, Metzger D
(2001) Proc Natl Acad Sci U S A 98: 224-8 - De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific.
Majka SM, Fox KE, Psilas JC, Helm KM, Childs CR, Acosta AS, Janssen RC, Friedman JE, Woessner BT, Shade TR, Varella-Garcia M, Klemm DJ
(2010) Proc Natl Acad Sci U S A 107: 14781-6 - Iron homeostasis: a new job for macrophages in adipose tissue?
Hubler MJ, Peterson KR, Hasty AH
(2015) Trends Endocrinol Metab 26: 101-9 - Calpains play a role in insulin secretion and action.
Sreenan SK, Zhou YP, Otani K, Hansen PA, Currie KP, Pan CY, Lee JP, Ostrega DM, Pugh W, Horikawa Y, Cox NJ, Hanis CL, Burant CF, Fox AP, Bell GI, Polonsky KS
(2001) Diabetes 50: 2013-20 - Fractalkine is a novel human adipochemokine associated with type 2 diabetes.
Shah R, Hinkle CC, Ferguson JF, Mehta NN, Li M, Qu L, Lu Y, Putt ME, Ahima RS, Reilly MP
(2011) Diabetes 60: 1512-8 - Concise review: adipocyte origins: weighing the possibilities.
Majka SM, Barak Y, Klemm DJ
(2011) Stem Cells 29: 1034-40 - Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.
Luo P, Dematteo A, Wang Z, Zhu L, Wang A, Kim HS, Pozzi A, Stafford JM, Luther JM
(2013) Diabetologia 56: 901-10 - Unique pathway for cholesterol uptake in fat cells.
Fazio S, Linton MF
(2004) Arterioscler Thromb Vasc Biol 24: 1538-9 - Tissue-specific RNA-Seq in human evoked inflammation identifies blood and adipose LincRNA signatures of cardiometabolic diseases.
Liu Y, Ferguson JF, Xue C, Ballantyne RL, Silverman IM, Gosai SJ, Serfecz J, Morley MP, Gregory BD, Li M, Reilly MP
(2014) Arterioscler Thromb Vasc Biol 34: 902-12 - Chronic ethanol consumption inhibits postlactational anabolic bone rebuilding in female rats.
Shankar K, Hidestrand M, Liu X, Chen JR, Haley R, Perrien DS, Skinner RA, Lumpkin CK, Badger TM, Ronis MJ
(2008) J Bone Miner Res 23: 338-49 - A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
Hagan GN, Lin Y, Magnuson MA, Avruch J, Czech MP
(2008) Mol Cell Biol 28: 4215-26 - Characterization of the Human Adipocyte Proteome and Reproducibility of Protein Abundance by One-Dimensional Gel Electrophoresis and HPLC-ESI-MS/MS.
Xie X, Yi Z, Bowen B, Wolf C, Flynn CR, Sinha S, Mandarino LJ, Meyer C
(2010) J Proteome Res 9: 4521-34 - Chronic ethanol feeding suppresses beta-adrenergic receptor-stimulated lipolysis in adipocytes isolated from epididymal fat.
Kang L, Nagy LE
(2006) Endocrinology 147: 4330-8 - AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.
Wang HY, Ducommun S, Quan C, Xie B, Li M, Wasserman DH, Sakamoto K, Mackintosh C, Chen S
(2013) Biochem J 449: 479-89 - Ligand-induced conformational changes modify proteolytic cleavage of the adipocyte insulin-sensitive glucose transporter.
Yano Y, May JM
(1993) Biochem J 295 ( Pt 1): 183-8 - Chronic ethanol and triglyceride turnover in white adipose tissue in rats: inhibition of the anti-lipolytic action of insulin after chronic ethanol contributes to increased triglyceride degradation.
Kang L, Chen X, Sebastian BM, Pratt BT, Bederman IR, Alexander JC, Previs SF, Nagy LE
(2007) J Biol Chem 282: 28465-73 - Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.
Inoue N, Yahagi N, Yamamoto T, Ishikawa M, Watanabe K, Matsuzaka T, Nakagawa Y, Takeuchi Y, Kobayashi K, Takahashi A, Suzuki H, Hasty AH, Toyoshima H, Yamada N, Shimano H
(2008) J Biol Chem 283: 21220-9 - Depletion of cAMP-response element-binding protein/ATF1 inhibits adipogenic conversion of 3T3-L1 cells ectopically expressing CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBP beta, or PPAR gamma 2.
Fox KE, Fankell DM, Erickson PF, Majka SM, Crossno JT, Klemm DJ
(2006) J Biol Chem 281: 40341-53 - Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA.
Oliver E, McGillicuddy FC, Harford KA, Reynolds CM, Phillips CM, Ferguson JF, Roche HM
(2012) J Nutr Biochem 23: 1192-200 - Plasminogen activator inhibitor-1 modulates adipocyte differentiation.
Liang X, Kanjanabuch T, Mao SL, Hao CM, Tang YW, Declerck PJ, Hasty AH, Wasserman DH, Fogo AB, Ma LJ
(2006) Am J Physiol Endocrinol Metab 290: E103-E113 - Autoimmune-mediated glucose intolerance in a mouse model of systemic lupus erythematosus.
Gabriel CL, Smith PB, Mendez-Fernandez YV, Wilhelm AJ, Ye AM, Major AS
(2012) Am J Physiol Endocrinol Metab 303: E1313-24 - Adipocyte Metabolic Pathways Regulated by Diet Control the Female Germline Stem Cell Lineage in .
Matsuoka S, Armstrong AR, Sampson LL, Laws KM, Drummond-Barbosa D
(2017) Genetics 206: 953-971 - Expression of the adipocyte fatty acid-binding protein in streptozotocin-diabetes: effects of insulin deficiency and supplementation.
Melki SA, Abumrad NA
(1993) J Lipid Res 34: 1527-34 - Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites.
Williams CP, Postic C, Robin D, Robin P, Parrinello J, Shelton K, Printz RL, Magnuson MA, Granner DK, Forest C, Chalkley R
(1999) Mol Cell Endocrinol 148: 67-77
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