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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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- Syk tyrosine kinase required for mouse viability and B-cell development.
Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T
(1995) Nature 378: 303-6 - Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.
Rickert RC, Rajewsky K, Roes J
(1995) Nature 376: 352-5 - Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis.
Vesa J, Hellsten E, Verkruyse LA, Camp LA, Rapola J, Santavuori P, Hofmann SL, Peltonen L
(1995) Nature 376: 584-7 - A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.
Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS
(2012) Nat Med 18: 1820-6 - The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.
Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB
(2003) Nat Med 9: 220-4 - Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.
Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, Shriver LP, Ledent C, Cheng X, Carrier EJ, Mann MK, Giovannoni G, Pertwee RG, Yamamura T, Buckley NE, Hillard CJ, Lutz B, Baker D, Dittel BN
(2007) Nat Med 13: 492-7 - Human lupus T cells resist inactivation and escape death by upregulating COX-2.
Xu L, Zhang L, Yi Y, Kang HK, Datta SK
(2004) Nat Med 10: 411-5 - Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer.
Roth JA, Nguyen D, Lawrence DD, Kemp BL, Carrasco CH, Ferson DZ, Hong WK, Komaki R, Lee JJ, Nesbitt JC, Pisters KM, Putnam JB, Schea R, Shin DM, Walsh GL, Dolormente MM, Han CI, Martin FD, Yen N, Xu K, Stephens LC, McDonnell TJ, Mukhopadhyay T, Cai D
(1996) Nat Med 2: 985-91 - A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.
Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, Gottfried Y, Birkey Reffey S, de Caestecker MP, Danielpour D, Book-Melamed N, Timberg R, Duckett CS, Lechleider RJ, Steller H, Orly J, Kim SJ, Roberts AB
(2000) Nat Cell Biol 2: 915-21 - Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder.
Kim SJ, Cox N, Courchesne R, Lord C, Corsello C, Akshoomoff N, Guter S, Leventhal BL, Courchesne E, Cook EH
(2002) Mol Psychiatry 7: 278-88 - Toward the construction of integrated physical and genetic maps of the mouse genome using interspersed repetitive sequence PCR (IRS-PCR) genomics.
Hunter KW, Riba L, Schalkwyk L, Clark M, Resenchuk S, Beeghly A, Su J, Tinkov F, Lee P, Ramu E, Lehrach H, Housman D
(1996) Genome Res 6: 290-9 - A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region.
Galili N, Baldwin HS, Lund J, Reeves R, Gong W, Wang Z, Roe BA, Emanuel BS, Nayak S, Mickanin C, Budarf MI, Buck CA
(1997) Genome Res 7: 399 - Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells.
Abbott DW, Freeman ML, Holt JT
(1998) J Natl Cancer Inst 90: 978-85 - E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas.
Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D, Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, Terashima M, Motoyama T, Meltzer SJ
(2000) J Natl Cancer Inst 92: 569-73 - Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans.
An G, Wei B, Xia B, McDaniel JM, Ju T, Cummings RD, Braun J, Xia L
(2007) J Exp Med 204: 1417-29 - Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule.
Cheng HF, Becker BN, Burns KD, Harris RC
(1995) J Clin Invest 95: 2012-9 - Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a).
Linton MF, Farese RV, Chiesa G, Grass DS, Chin P, Hammer RE, Hobbs HH, Young SG
(1993) J Clin Invest 92: 3029-37 - The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.
Muraoka RS, Sun WY, Colbert MC, Waltz SE, Witte DP, Degen JL, Friezner Degen SJ
(1999) J Clin Invest 103: 1277-85 - C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas.
Kern JA, Slebos RJ, Top B, Rodenhuis S, Lager D, Robinson RA, Weiner D, Schwartz DA
(1994) J Clin Invest 93: 516-20 - Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner.
Woo KV, Qu X, Babaev VR, Linton MF, Guzman RJ, Fazio S, Baldwin HS
(2011) J Clin Invest 121: 1624-35 - Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload.
Senbonmatsu T, Ichihara S, Price E, Gaffney FA, Inagami T
(2000) J Clin Invest 106: R25-9 - A proximal activator of transcription in epithelial-mesenchymal transition.
Venkov CD, Link AJ, Jennings JL, Plieth D, Inoue T, Nagai K, Xu C, Dimitrova YN, Rauscher FJ, Neilson EG
(2007) J Clin Invest 117: 482-91 - The α₂β₁ integrin is a metastasis suppressor in mouse models and human cancer.
Ramirez NE, Zhang Z, Madamanchi A, Boyd KL, O'Rear LD, Nashabi A, Li Z, Dupont WD, Zijlstra A, Zutter MM
(2011) J Clin Invest 121: 226-37 - Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors.
Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE
(2006) Genes Dev 20: 1496-510 - Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo.
Hanna LA, Foreman RK, Tarasenko IA, Kessler DS, Labosky PA
(2002) Genes Dev 16: 2650-61 - TFIIF-TAF-RNA polymerase II connection.
Henry NL, Campbell AM, Feaver WJ, Poon D, Weil PA, Kornberg RD
(1994) Genes Dev 8: 2868-78 - Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.
Zou L, Cortez D, Elledge SJ
(2002) Genes Dev 16: 198-208 - Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves.
Chen JW, Zhou B, Yu QC, Shin SJ, Jiao K, Schneider MD, Baldwin HS, Bergelson JM
(2006) Circ Res 98: 923-30 - RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies.
Antoniou AC, Sinilnikova OM, Simard J, Léoné M, Dumont M, Neuhausen SL, Struewing JP, Stoppa-Lyonnet D, Barjhoux L, Hughes DJ, Coupier I, Belotti M, Lasset C, Bonadona V, Bignon YJ, Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers Study (GEMO), Rebbeck TR, Wagner T, Lynch HT, Domchek SM, Nathanson KL, Garber JE, Weitzel J, Narod SA, Tomlinson G, Olopade OI, Godwin A, Isaacs C, Jakubowska A, Lubinski J, Gronwald J, Górski B, Byrski T, Huzarski T, Peock S, Cook M, Baynes C, Murray A, Rogers M, Daly PA, Dorkins H, Epidemiological Study of BRCA1 and BRCA2 Mutation Carriers (EMBRACE), Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Niederacher D, Deissler H, German Consortium for Hereditary Breast and Ovarian Cancer (GCHBOC), Spurdle AB, Chen X, Waddell N, Cloonan N, Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab), Kirchhoff T, Offit K, Friedman E, Kaufmann B, Laitman Y, Galore G, Rennert G, Lejbkowicz F, Raskin L, Andrulis IL, Ilyushik E, Ozcelik H, Devilee P, Vreeswijk MP, Greene MH, Prindiville SA, Osorio A, Benitez J, Zikan M, Szabo CI, Kilpivaara O, Nevanlinna H, Hamann U, Durocher F, Arason A, Couch FJ, Easton DF, Chenevix-Trench G, Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)
(2007) Am J Hum Genet 81: 1186-200 - Haplotypes of angiotensinogen in essential hypertension.
Jeunemaitre X, Inoue I, Williams C, Charru A, Tichet J, Powers M, Sharma AM, Gimenez-Roqueplo AP, Hata A, Corvol P, Lalouel JM
(1997) Am J Hum Genet 60: 1448-60 - Assessing the functional characteristics of synonymous and nonsynonymous mutation candidates by use of large DNA constructs.
Eeds AM, Mortlock D, Wade-Martins R, Summar ML
(2007) Am J Hum Genet 80: 740-50 - Microdeletion of LIT1 in familial Beckwith-Wiedemann syndrome.
Niemitz EL, DeBaun MR, Fallon J, Murakami K, Kugoh H, Oshimura M, Feinberg AP
(2004) Am J Hum Genet 75: 844-9 - p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells.
Aono S, Nakagawa S, Reynolds AB, Takeichi M
(1999) J Cell Biol 145: 551-62 - Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice.
Schulla V, Renström E, Feil R, Feil S, Franklin I, Gjinovci A, Jing XJ, Laux D, Lundquist I, Magnuson MA, Obermüller S, Olofsson CS, Salehi A, Wendt A, Klugbauer N, Wollheim CB, Rorsman P, Hofmann F
(2003) EMBO J 22: 3844-54 - Cyanobacterial circadian clockwork: roles of KaiA, KaiB and the kaiBC promoter in regulating KaiC.
Xu Y, Mori T, Johnson CH
(2003) EMBO J 22: 2117-26 - Circadian clock-protein expression in cyanobacteria: rhythms and phase setting.
Xu Y, Mori T, Johnson CH
(2000) EMBO J 19: 3349-57 - Visual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae.
Merrill CE, Riesgo-Escovar J, Pitts RJ, Kafatos FC, Carlson JR, Zwiebel LJ
(2002) Proc Natl Acad Sci U S A 99: 1633-8 - Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.
Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG
(1995) Proc Natl Acad Sci U S A 92: 4917-21 - A highly conserved candidate chemoreceptor expressed in both olfactory and gustatory tissues in the malaria vector Anopheles gambiae.
Pitts RJ, Fox AN, Zwiebel LJ
(2004) Proc Natl Acad Sci U S A 101: 5058-63 - Wnt signaling potentiates nevogenesis.
Pawlikowski JS, McBryan T, van Tuyn J, Drotar ME, Hewitt RN, Maier AB, King A, Blyth K, Wu H, Adams PD
(2013) Proc Natl Acad Sci U S A 110: 16009-14
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