Keyword Connections

•  Changqing Zhang

•  Jennifer Skelton

•  Mark Magnuson

Resources

• Antibiotic selection of gene targeted mESCs
• Gene targeting and exchange vector guidelines
• pFRT.LoxP
• pMCS.DT-A

Communities

• No matching connections

Publications

• Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.
  Ichiki T, Labosky PA, Shiota C, Okuyama S, Imagawa Y, Fogo A, Niimura F, Ichikawa I, Hogan BL, Inagami T
  (1995) Nature 377: 748-50
• Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.
  Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R
  (2000) Nature 405: 966-70
• Disruption of IRS-2 causes type 2 diabetes in mice.
  Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF
  (1998) Nature 391: 900-4
• The transcription factor NF-ATc is essential for cardiac valve formation.
  Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH
  (1998) Nature 392: 186-90
• Mox2 is a component of the genetic hierarchy controlling limb muscle development.
  Mankoo BS, Collins NS, Ashby P, Grigorieva E, Pevny LH, Candia A, Wright CV, Rigby PW, Pachnis V
  (1999) Nature 400: 69-73
• Generalized lacZ expression with the ROSA26 Cre reporter strain.
  Soriano P
  (1999) Nat Genet 21: 70-1
• Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.
  Hoogenraad CC, Koekkoek B, Akhmanova A, Krugers H, Dortland B, Miedema M, van Alphen A, Kistler WM, Jaegle M, Koutsourakis M, Van Camp N, Verhoye M, van der Linden A, Kaverina I, Grosveld F, De Zeeuw CI, Galjart N
  (2002) Nat Genet 32: 116-27
• Functional genomics in mice by tagged sequence mutagenesis.
  Hicks GG, Shi EG, Li XM, Li CH, Pawlak M, Ruley HE
  (1997) Nat Genet 16: 338-44
• Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.
  Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG
  (2000) Nat Genet 26: 336-40
• A conditionally replicating adenovirus targeted to tumor cells through activated RAS/P-MAPK-selective mRNA stabilization.
  Ahmed A, Thompson J, Emiliusen L, Murphy S, Beauchamp RD, Suzuki K, Alemany R, Harrington K, Vile RG
  (2003) Nat Biotechnol 21: 771-7
• Genetic engineering of human pluripotent cells using TALE nucleases.
  Hockemeyer D, Wang H, Kiani S, Lai CS, Gao Q, Cassady JP, Cost GJ, Zhang L, Santiago Y, Miller JC, Zeitler B, Cherone JM, Meng X, Hinkley SJ, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R
  (2011) Nat Biotechnol 29: 731-4
• AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.
  Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR
  (1996) Cell 84: 321-30
• Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein.
  Lefebvre O, Chenard MP, Masson R, Linares J, Dierich A, LeMeur M, Wendling C, Tomasetto C, Chambon P, Rio MC
  (1996) Science 274: 259-62
• Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.
  Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC
  (1995) Science 269: 230-4
• Trefoil peptides: less clandestine in the intestine.
  Chinery R, Coffey RJ
  (1996) Science 274: 204
• Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery.
  Wei J, Blum S, Unger M, Jarmy G, Lamparter M, Geishauser A, Vlastos GA, Chan G, Fischer KD, Rattat D, Debatin KM, Hatzopoulos AK, Beltinger C
  (2004) Cancer Cell 5: 477-88
• Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption.
  Guan Y, Hao C, Cha DR, Rao R, Lu W, Kohan DE, Magnuson MA, Redha R, Zhang Y, Breyer MD
  (2005) Nat Med 11: 861-6
• High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9.
  Varshney GK, Pei W, LaFave MC, Idol J, Xu L, Gallardo V, Carrington B, Bishop K, Jones M, Li M, Harper U, Huang SC, Prakash A, Chen W, Sood R, Ledin J, Burgess SM
  (2015) Genome Res 25: 1030-42
• Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.
  Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA
  (2006) Dev Cell 11: 583-9
• Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells.
  Matsusaka T, Nishimura H, Utsunomiya H, Kakuchi J, Niimura F, Inagami T, Fogo A, Ichikawa I
  (1996) J Clin Invest 98: 1867-77
• The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.
  Zhao GQ, Deng K, Labosky PA, Liaw L, Hogan BL
  (1996) Genes Dev 10: 1657-69
• Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
  Lawson KA, Dunn NR, Roelen BA, Zeinstra LM, Davis AM, Wright CV, Korving JP, Hogan BL
  (1999) Genes Dev 13: 424-36
• Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
  Winnier G, Blessing M, Labosky PA, Hogan BL
  (1995) Genes Dev 9: 2105-16
• Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system.
  Kupershmidt S, Yang T, Anderson ME, Wessels A, Niswender KD, Magnuson MA, Roden DM
  (1999) Circ Res 84: 146-52
• Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome.
  Miner JH, Sanes JR
  (1996) J Cell Biol 135: 1403-13
• The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death.
  Casademunt E, Carter BD, Benzel I, Frade JM, Dechant G, Barde YA
  (1999) EMBO J 18: 6050-61
• Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development.
  Ji QS, Winnier GE, Niswender KD, Horstman D, Wisdom R, Magnuson MA, Carpenter G
  (1997) Proc Natl Acad Sci U S A 94: 2999-3003
• Neurotensin-deficient mice show altered responses to antipsychotic drugs.
  Dobner PR, Fadel J, Deitemeyer N, Carraway RE, Deutch AY
  (2001) Proc Natl Acad Sci U S A 98: 8048-53
• NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo.
  Bertrand MJ, Kenchappa RS, Andrieu D, Leclercq-Smekens M, Nguyen HN, Carter BD, Muscatelli F, Barker PA, De Backer O
  (2008) Cell Death Differ 15: 1921-9
• A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.
  Mussolino C, Morbitzer R, Lütge F, Dannemann N, Lahaye T, Cathomen T
  (2011) Nucleic Acids Res 39: 9283-93
• Mutagenesis of diploid mammalian genes by gene entrapment.
  Lin Q, Donahue SL, Moore-Jarrett T, Cao S, Osipovich AB, Ruley HE
  (2006) Nucleic Acids Res 34: e139
• Comparative analysis of chimeric ZFP-, TALE- and Cas9-piggyBac transposases for integration into a single locus in human cells.
  Luo W, Galvan DL, Woodard LE, Dorset D, Levy S, Wilson MH
  (2017) Nucleic Acids Res 45: 8411-8422
• Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.
  Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MG, Gannon M, Powers AC, Dempsey PJ
  (2010) Diabetes 59: 3090-8
• Electroporation of murine embryonic stem cells: a step-by-step guide.
  Tompers DM, Labosky PA
  (2004) Stem Cells 22: 243-9
• Genetic targeting of adenovirus vectors using a reovirus sigma1-based attachment protein.
  Schagen FH, Wensveen FM, Carette JE, Dermody TS, Gerritsen WR, van Beusechem VW
  (2006) Mol Ther 13: 997-1005
• Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish.
  Kim SH, Shin J, Park HC, Yeo SY, Hong SK, Han S, Rhee M, Kim CH, Chitnis AB, Huh TL
  (2002) Development 129: 4443-55
• Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory.
  Doll CA, Broadie K
  (2015) Development 142: 1346-56
• Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity.
  Goldman DC, Hackenmiller R, Nakayama T, Sopory S, Wong C, Kulessa H, Christian JL
  (2006) Development 133: 1933-42
• Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
  Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS
  (1998) Development 125: 2213-21
• The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting.
  Haase VH
  (2005) Semin Cell Dev Biol 16: 564-74