Keyword Connections

•  Jorge Gamboa
•  Joshua Fessel

•  Julie Bastarache
•  Louise Lantier

•  Sergey Dikalov

Resources

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Communities

• Metabolism Interest Group

Publications

• Telomere dysfunction induces metabolic and mitochondrial compromise.
  Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA
  (2011) Nature 470: 359-65
• An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
  Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S, Korsmeyer SJ, Kunzer AR, Letai A, Li C, Mitten MJ, Nettesheim DG, Ng S, Nimmer PM, O'Connor JM, Oleksijew A, Petros AM, Reed JC, Shen W, Tahir SK, Thompson CB, Tomaselli KJ, Wang B, Wendt MD, Zhang H, Fesik SW, Rosenberg SH
  (2005) Nature 435: 677-81
• Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis.
  Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA, Korsmeyer SJ
  (1999) Nature 400: 886-91
• A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes.
  Cree LM, Samuels DC, de Sousa Lopes SC, Rajasimha HK, Wonnapinij P, Mann JR, Dahl HH, Chinnery PF
  (2008) Nat Genet 40: 249-54
• Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations.
  Payne BA, Wilson IJ, Hateley CA, Horvath R, Santibanez-Koref M, Samuels DC, Price DA, Chinnery PF
  (2011) Nat Genet 43: 806-10
• Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
  Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP
  (2012) Cell 149: 49-62
• Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
  Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA
  (2013) Cell 155: 1624-38
• Insights into programmed cell death through structural biology.
  Fesik SW
  (2000) Cell 103: 273-82
• Structural biology. Controlling the caspases.
  Fesik SW, Shi Y
  (2001) Science 294: 1477-8
• Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.
  Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, Liao R, Walsh D, Sedivy J, Murphy DJ, Carrasco DR, Robinson S, Moslehi J, Letai A
  (2017) Cancer Cell 31: 142-156
• A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.
  Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, Gottfried Y, Birkey Reffey S, de Caestecker MP, Danielpour D, Book-Melamed N, Timberg R, Duckett CS, Lechleider RJ, Steller H, Orly J, Kim SJ, Roberts AB
  (2000) Nat Cell Biol 2: 915-21
• RNA editing.
  Simpson L, Emeson RB
  (1996) Annu Rev Neurosci 19: 27-52
• Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
  Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SSW, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP
  (2014) Neuron 81: 536-543
• p53 has a direct apoptogenic role at the mitochondria.
  Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM
  (2003) Mol Cell 11: 577-90
• Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis.
  Dumitru R, Gama V, Fagan BM, Bower JJ, Swahari V, Pevny LH, Deshmukh M
  (2012) Mol Cell 46: 573-83
• Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.
  Moslehi J, Minamishima YA, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG
  (2010) Circulation 122: 1004-16
• PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression.
  Gauthier BR, Wiederkehr A, Baquié M, Dai C, Powers AC, Kerr-Conte J, Pattou F, MacDonald RJ, Ferrer J, Wollheim CB
  (2009) Cell Metab 10: 110-8
• MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.
  Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders ME, Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC, Fesik SW, Arteaga CL
  (2017) Cell Metab 26: 633-647.e7
• AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
  Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC
  (2016) Cell Metab 23: 649-62
• SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
  Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA
  (2012) Cell Metab 15: 675-90
• Differences in lymphocyte electron transport gene expression levels between subjects with bipolar disorder and normal controls in response to glucose deprivation stress.
  Naydenov AV, MacDonald ML, Ongur D, Konradi C
  (2007) Arch Gen Psychiatry 64: 555-64
• Molecular evidence for mitochondrial dysfunction in bipolar disorder.
  Konradi C, Eaton M, MacDonald ML, Walsh J, Benes FM, Heckers S
  (2004) Arch Gen Psychiatry 61: 300-8
• Superparamagnetic nanoparticles as a powerful systems biology characterization tool in the physiological context.
  Salaklang J, Steitz B, Finka A, O'Neil CP, Moniatte M, van der Vlies AJ, Giorgio TD, Hofmann H, Hubbell JA, Petri-Fink A
  (2008) Angew Chem Int Ed Engl 47: 7857-60
• Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans.
  Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, Price JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD
  (2009) J Clin Invest 119: 573-81
• Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
  Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Livingston K, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC
  (2015) J Clin Invest 125: 4447-62
• Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.
  Bordicchia M, Liu D, Amri EZ, Ailhaud G, Dessì-Fulgheri P, Zhang C, Takahashi N, Sarzani R, Collins S
  (2012) J Clin Invest 122: 1022-36
• p62 links β-adrenergic input to mitochondrial function and thermogenesis.
  Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH
  (2013) J Clin Invest 123: 469-78
• Diabetes increases mortality after myocardial infarction by oxidizing CaMKII.
  Luo M, Guan X, Luczak ED, Lang D, Kutschke W, Gao Z, Yang J, Glynn P, Sossalla S, Swaminathan PD, Weiss RM, Yang B, Rokita AG, Maier LS, Efimov IR, Hund TJ, Anderson ME
  (2013) J Clin Invest 123: 1262-74
• Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models.
  Brooks C, Wei Q, Cho SG, Dong Z
  (2009) J Clin Invest 119: 1275-85
• p66(shc)'s role as an essential mitophagic molecule in controlling neuronal redox and energetic tone.
  Kleman AM, Brown JE, Zeiger SL, Hettinger JC, Brooks JD, Holt B, Morrow JD, Musiek ES, Milne GL, McLaughlin B
  (2010) Autophagy 6: 948-9
• Telomeres and mitochondria in the aging heart.
  Moslehi J, DePinho RA, Sahin E
  (2012) Circ Res 110: 1226-37
• Therapeutic targeting of mitochondrial superoxide in hypertension.
  Dikalova AE, Bikineyeva AT, Budzyn K, Nazarewicz RR, McCann L, Lewis W, Harrison DG, Dikalov SI
  (2010) Circ Res 107: 106-16
• Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction.
  Doughan AK, Harrison DG, Dikalov SI
  (2008) Circ Res 102: 488-96
• Mitochondrial oxidative stress in heart failure: "oxygen wastage" revisited.
  Sawyer DB, Colucci WS
  (2000) Circ Res 86: 119-20
• Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway.
  Remondino A, Kwon SH, Communal C, Pimentel DR, Sawyer DB, Singh K, Colucci WS
  (2003) Circ Res 92: 136-8
• The organization of the transcriptional network in specific neuronal classes.
  Winden KD, Oldham MC, Mirnics K, Ebert PJ, Swan CH, Levitt P, Rubenstein JL, Horvath S, Geschwind DH
  (2009) Mol Syst Biol 5: 291
• Programming biological models in Python using PySB.
  Lopez CF, Muhlich JL, Bachman JA, Sorger PK
  (2013) Mol Syst Biol 9: 646
• Previous estimates of mitochondrial DNA mutation level variance did not account for sampling error: comparing the mtDNA genetic bottleneck in mice and humans.
  Wonnapinij P, Chinnery PF, Samuels DC
  (2010) Am J Hum Genet 86: 540-50
• Relaxed replication of mtDNA: A model with implications for the expression of disease.
  Chinnery PF, Samuels DC
  (1999) Am J Hum Genet 64: 1158-65
• Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.
  Elson JL, Samuels DC, Turnbull DM, Chinnery PF
  (2001) Am J Hum Genet 68: 802-6