Keyword Connections

•  Ariel Deutch
•  Corey Hopkins
•  Eugenia Gurevich

•  Karoly Mirnics
•  Peter Conn
•  Sohee Park

•  Stephan Heckers
•  Wayne Ray

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Publications

• Disability income, cocaine use, and repeated hospitalization among schizophrenic cocaine abusers--a government-sponsored revolving door?
  Shaner A, Eckman TA, Roberts LJ, Wilkins JN, Tucker DE, Tsuang JW, Mintz J
  (1995) N Engl J Med 333: 777-83
• Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.
  Huckins LM, Dobbyn A, Ruderfer DM, Hoffman G, Wang W, Pardiñas AF, Rajagopal VM, Als TD, T Nguyen H, Girdhar K, Boocock J, Roussos P, Fromer M, Kramer R, Domenici E, Gamazon ER, Purcell S, CommonMind Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, iPSYCH-GEMS Schizophrenia Working Group, Demontis D, Børglum AD, Walters JTR, O'Donovan MC, Sullivan P, Owen MJ, Devlin B, Sieberts SK, Cox NJ, Im HK, Sklar P, Stahl EA
  (2019) Nat Genet 51: 659-674
• Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
  Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayés M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DH, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisén L, Gallagher L, Gejman PV, Georgieva L, Gershon ES, Geschwind DH, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green EK, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan W, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath AC, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holmans PA, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kähler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim Y, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landén M, Långström N, Lathrop M, Lawrence J, Lawson WB, Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, MacIntyre DJ, Madden PA, Maestrini E, Magnusson PK, Mahon PB, Maier W, Malhotra AK, Mane SM, Martin CL, Martin NG, Mattheisen M, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough JJ, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon WM, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp CM, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Mühleisen TW, Muir WJ, Müller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nöthen MM, Nurnberger JI, Nwulia EA, Nyholt DR, O'Dushlaine C, Oades RD, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson AD, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Posthuma D, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga JA, Rasmussen HB, Raychaudhuri S, Rehnström K, Reif A, Ribasés M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rossin L, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders AR, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner WA, Schellenberg GD, Scherer SW, Schork NJ, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi J, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith EN, Sonuga-Barke EJ, St Clair D, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier J, Stroup TS, Sutcliffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov AA, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Van Os J, Vicente AM, Vieland VJ, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker TF, Wijsman EM, Willemsen G, Williams N, Willsey AJ, Witt SH, Xu W, Young AH, Yu TW, Zammit S, Zandi PP, Zhang P, Zitman FG, Zöllner S, Devlin B, Kelsoe JR, Sklar P, Daly MJ, O'Donovan MC, Craddock N, Sullivan PF, Smoller JW, Kendler KS, Wray NR, International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)
  (2013) Nat Genet 45: 984-94
• Microduplications of 16p11.2 are associated with schizophrenia.
  McCarthy SE, Makarov V, Kirov G, Addington AM, McClellan J, Yoon S, Perkins DO, Dickel DE, Kusenda M, Krastoshevsky O, Krause V, Kumar RA, Grozeva D, Malhotra D, Walsh T, Zackai EH, Kaplan P, Ganesh J, Krantz ID, Spinner NB, Roccanova P, Bhandari A, Pavon K, Lakshmi B, Leotta A, Kendall J, Lee YH, Vacic V, Gary S, Iakoucheva LM, Crow TJ, Christian SL, Lieberman JA, Stroup TS, Lehtimäki T, Puura K, Haldeman-Englert C, Pearl J, Goodell M, Willour VL, Derosse P, Steele J, Kassem L, Wolff J, Chitkara N, McMahon FJ, Malhotra AK, Potash JB, Schulze TG, Nöthen MM, Cichon S, Rietschel M, Leibenluft E, Kustanovich V, Lajonchere CM, Sutcliffe JS, Skuse D, Gill M, Gallagher L, Mendell NR, Wellcome Trust Case Control Consortium, Craddock N, Owen MJ, O'Donovan MC, Shaikh TH, Susser E, Delisi LE, Sullivan PF, Deutsch CK, Rapoport J, Levy DL, King MC, Sebat J
  (2009) Nat Genet 41: 1223-7
• Breaking the gene barrier in schizophrenia.
  Horváth S, Mirnics K
  (2009) Nat Med 15: 488-90
• Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection.
  Lieberman JA, Bymaster FP, Meltzer HY, Deutch AY, Duncan GE, Marx CE, Aprille JR, Dwyer DS, Li XM, Mahadik SP, Duman RS, Porter JH, Modica-Napolitano JS, Newton SS, Csernansky JG
  (2008) Pharmacol Rev 60: 358-403
• Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex.
  Mirnics K, Middleton FA, Marquez A, Lewis DA, Levitt P
  (2000) Neuron 28: 53-67
• Multisensory Integration as a Window into Orderly and Disrupted Cognition and Communication.
  Wallace MT, Woynaroski TG, Stevenson RA
  (2020) Annu Rev Psychol 71: 193-219
• Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes.
  Brown JA, Ramikie TS, Schmidt MJ, Báldi R, Garbett K, Everheart MG, Warren LE, Gellért L, Horváth S, Patel S, Mirnics K
  (2015) Mol Psychiatry 20: 1499-507
• Acute amygdalar activation induces an upregulation of multiple monoamine G protein coupled pathways in rat hippocampus.
  Benes FM, Burke RE, Walsh J, Berretta S, Matzilevich D, Minns M, Konradi C
  (2004) Mol Psychiatry 9: 932-45, 895
• Novel animal models for studying complex brain disorders: BAC-driven miRNA-mediated in vivo silencing of gene expression.
  Garbett KA, Horváth S, Ebert PJ, Schmidt MJ, Lwin K, Mitchell A, Levitt P, Mirnics K
  (2010) Mol Psychiatry 15: 987-95
• SZGR: a comprehensive schizophrenia gene resource.
  Jia P, Sun J, Guo AY, Zhao Z
  (2010) Mol Psychiatry 15: 453-62
• Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia.
  Mirnics K, Middleton FA, Stanwood GD, Lewis DA, Levitt P
  (2001) Mol Psychiatry 6: 293-301
• Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia.
  Hashimoto T, Arion D, Unger T, Maldonado-Avilés JG, Morris HM, Volk DW, Mirnics K, Lewis DA
  (2008) Mol Psychiatry 13: 147-61
• Thalamocortical dysconnectivity in schizophrenia.
  Woodward ND, Karbasforoushan H, Heckers S
  (2012) Am J Psychiatry 169: 1092-9
• Altered functional and structural connectivity in a schizophrenia patient with complete agenesis of the corpus callosum.
  Rane S, Kose S, Gore JC, Heckers S
  (2013) Am J Psychiatry 170: 122-3
• Preliminary evidence of improved verbal working memory performance and normalization of task-related frontal lobe activation in schizophrenia following cognitive exercises.
  Wexler BE, Anderson M, Fulbright RK, Gore JC
  (2000) Am J Psychiatry 157: 1694-7
• Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia.
  Hashimoto T, Bazmi HH, Mirnics K, Wu Q, Sampson AR, Lewis DA
  (2008) Am J Psychiatry 165: 479-89
• Hyperactivity and Reduced Activation of Anterior Hippocampus in Early Psychosis.
  McHugo M, Talati P, Armstrong K, Vandekar SN, Blackford JU, Woodward ND, Heckers S
  (2019) Am J Psychiatry 176: 1030-1038
• The human genome: gene expression profiling and schizophrenia.
  Mirnics K, Middleton FA, Lewis DA, Levitt P
  (2001) Am J Psychiatry 158: 1384
• Altered brain activation during action imitation and observation in schizophrenia: a translational approach to investigating social dysfunction in schizophrenia.
  Thakkar KN, Peterman JS, Park S
  (2014) Am J Psychiatry 171: 539-48
• "Splitting of the mind" revisited: recent neuroimaging evidence for functional dysconnection in schizophrenia and its relation to symptoms.
  Park S, Thakkar KN
  (2010) Am J Psychiatry 167: 366-8
• Spatial working memory deficits in the relatives of schizophrenic patients.
  Park S, Holzman PS, Goldman-Rakic PS
  (1995) Arch Gen Psychiatry 52: 821-8
• Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging.
  Stevens AA, Goldman-Rakic PS, Gore JC, Fulbright RK, Wexler BE
  (1998) Arch Gen Psychiatry 55: 1097-103
• The neural basis of relational memory deficits in schizophrenia.
  Ongür D, Cullen TJ, Wolf DH, Rohan M, Barreira P, Zalesak M, Heckers S
  (2006) Arch Gen Psychiatry 63: 356-65
• Molecular evidence for mitochondrial dysfunction in bipolar disorder.
  Konradi C, Eaton M, MacDonald ML, Walsh J, Benes FM, Heckers S
  (2004) Arch Gen Psychiatry 61: 300-8
• Schizophrenics show spatial working memory deficits.
  Park S, Holzman PS
  (1992) Arch Gen Psychiatry 49: 975-82
• Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia.
  Lisman JE, Coyle JT, Green RW, Javitt DC, Benes FM, Heckers S, Grace AA
  (2008) Trends Neurosci 31: 234-42
• Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse.
  Mirnics K, Middleton FA, Lewis DA, Levitt P
  (2001) Trends Neurosci 24: 479-86
• Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample.
  Suarez BK, Duan J, Sanders AR, Hinrichs AL, Jin CH, Hou C, Buccola NG, Hale N, Weilbaecher AN, Nertney DA, Olincy A, Green S, Schaffer AW, Smith CJ, Hannah DE, Rice JP, Cox NJ, Martinez M, Mowry BJ, Amin F, Silverman JM, Black DW, Byerley WF, Crowe RR, Freedman R, Cloninger CR, Levinson DF, Gejman PV
  (2006) Am J Hum Genet 78: 315-33
• Synchronizing theta oscillations with direct-current stimulation strengthens adaptive control in the human brain.
  Reinhart RM, Zhu J, Park S, Woodman GF
  (2015) Proc Natl Acad Sci U S A 112: 9448-53
• Cognition, schizophrenia, and the atypical antipsychotic drugs.
  Meltzer HY, Park S, Kessler R
  (1999) Proc Natl Acad Sci U S A 96: 13591-3
• Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder.
  Hart AB, Gamazon ER, Engelhardt BE, Sklar P, Kähler AK, Hultman CM, Sullivan PF, Neale BM, Faraone SV, Psychiatric Genomics Consortium: ADHD Subgroup, de Wit H, Cox NJ, Palmer AA
  (2014) Proc Natl Acad Sci U S A 111: 5968-73
• Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region.
  Wang AY, Lohmann KM, Yang CK, Zimmerman EI, Pantazopoulos H, Herring N, Berretta S, Heckers S, Konradi C
  (2011) Acta Neuropathol 122: 615-26
• Targeting glutamate synapses in schizophrenia.
  Field JR, Walker AG, Conn PJ
  (2011) Trends Mol Med 17: 689-98
• Genes and subtypes of schizophrenia.
  Mirnics K, Lewis DA
  (2001) Trends Mol Med 7: 281-3
• Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders.
  Conn PJ, Jones CK, Lindsley CW
  (2009) Trends Pharmacol Sci 30: 148-55
• Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.
  Conn PJ, Lindsley CW, Jones CK
  (2009) Trends Pharmacol Sci 30: 25-31
• Response inhibition and response monitoring in a saccadic countermanding task in schizophrenia.
  Thakkar KN, Schall JD, Boucher L, Logan GD, Park S
  (2011) Biol Psychiatry 69: 55-62