Keyword Connections

•  Adam Seegmiller
•  Ambra Pozzi
•  Anne Kenworthy
•  Brian Christman
•  Charles Flynn
•  Claus Schneider

•  Colleen Lawrence
•  David Aronoff
•  J Greg Terry
•  John Stafford
•  Jordan Best
•  Masakazu Shiota

•  Qi Zhang
•  Raymond Blind
•  Sean Davies
•  W. Jerome

Resources

• Analytical Resources Core
• Lipid Core Cost for Investigator-Initiated Services
• MetabIG Meeting

Communities

• Davies Lab
• Hormone Assay and Analytical Services Core
• Metabolism Interest Group

Publications

• Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage.
  Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts LJ
  (1995) N Engl J Med 332: 1198-203
• Introduction to lipid biochemistry, metabolism, and signaling.
  Brown HA, Marnett LJ
  (2011) Chem Rev 111: 5817-20
• Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research.
  Norris JL, Caprioli RM
  (2013) Chem Rev 113: 2309-42
• Isoprostane generation and function.
  Milne GL, Yin H, Hardy KD, Davies SS, Roberts LJ
  (2011) Chem Rev 111: 5973-96
• Free radical lipid peroxidation: mechanisms and analysis.
  Yin H, Xu L, Porter NA
  (2011) Chem Rev 111: 5944-72
• MALDI imaging of lipid biochemistry in tissues by mass spectrometry.
  Berry KA, Hankin JA, Barkley RM, Spraggins JM, Caprioli RM, Murphy RC
  (2011) Chem Rev 111: 6491-512
• Increased lipid peroxidation in patients with rhabdomyolysis.
  Holt S, Reeder B, Wilson M, Harvey S, Morrow JD, Roberts LJ, Moore K
  (1999) Lancet 353: 1241
• Structural and molecular interrogation of intact biological systems.
  Chung K, Wallace J, Kim SY, Kalyanasundaram S, Andalman AS, Davidson TJ, Mirzabekov JJ, Zalocusky KA, Mattis J, Denisin AK, Pak S, Bernstein H, Ramakrishnan C, Grosenick L, Gradinaru V, Deisseroth K
  (2013) Nature 497: 332-7
• A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.
  Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH
  (2013) Nature 502: 550-4
• Bcl-x(L) forms an ion channel in synthetic lipid membranes.
  Minn AJ, Vélez P, Schendel SL, Liang H, Muchmore SW, Fesik SW, Fill M, Thompson CB
  (1997) Nature 385: 353-7
• Cell-programmed nutrient partitioning in the tumour microenvironment.
  Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, Todd VM, Huffstater T, Abraham A, O'Neil RT, Wilson MH, Xin F, Tantawy MN, Merryman WD, Johnson RW, Williams CS, Mason EF, Mason FM, Beckermann KE, Vander Heiden MG, Manning HC, Rathmell JC, Rathmell WK
  (2021) Nature 593: 282-288
• Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.
  Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH, Boyd K, Sleeman MW, Oliver G
  (2005) Nat Genet 37: 1072-81
• Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.
  Lu X, Peloso GM, Liu DJ, Wu Y, Zhang H, Zhou W, Li J, Tang CS, Dorajoo R, Li H, Long J, Guo X, Xu M, Spracklen CN, Chen Y, Liu X, Zhang Y, Khor CC, Liu J, Sun L, Wang L, Gao YT, Hu Y, Yu K, Wang Y, Cheung CYY, Wang F, Huang J, Fan Q, Cai Q, Chen S, Shi J, Yang X, Zhao W, Sheu WH, Cherny SS, He M, Feranil AB, Adair LS, Gordon-Larsen P, Du S, Varma R, Chen YI, Shu XO, Lam KSL, Wong TY, Ganesh SK, Mo Z, Hveem K, Fritsche LG, Nielsen JB, Tse HF, Huo Y, Cheng CY, Chen YE, Zheng W, Tai ES, Gao W, Lin X, Huang W, Abecasis G, GLGC Consortium, Kathiresan S, Mohlke KL, Wu T, Sham PC, Gu D, Willer CJ
  (2017) Nat Genet 49: 1722-1730
• Exome-wide association study of plasma lipids in >300,000 individuals.
  Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC, Boehnke M, Boerwinkle E, Bork-Jensen J, Bottinger EP, Brandslund I, Brown M, Busonero F, Caulfield MJ, Chambers JC, Chasman DI, Chen YE, Chen YI, Chowdhury R, Christensen C, Chu AY, Connell JM, Cucca F, Cupples LA, Damrauer SM, Davies G, Deary IJ, Dedoussis G, Denny JC, Dominiczak A, Dubé MP, Ebeling T, Eiriksdottir G, Esko T, Farmaki AE, Feitosa MF, Ferrario M, Ferrieres J, Ford I, Fornage M, Franks PW, Frayling TM, Frikke-Schmidt R, Fritsche LG, Frossard P, Fuster V, Ganesh SK, Gao W, Garcia ME, Gieger C, Giulianini F, Goodarzi MO, Grallert H, Grarup N, Groop L, Grove ML, Gudnason V, Hansen T, Harris TB, Hayward C, Hirschhorn JN, Holmen OL, Huffman J, Huo Y, Hveem K, Jabeen S, Jackson AU, Jakobsdottir J, Jarvelin MR, Jensen GB, Jørgensen ME, Jukema JW, Justesen JM, Kamstrup PR, Kanoni S, Karpe F, Kee F, Khera AV, Klarin D, Koistinen HA, Kooner JS, Kooperberg C, Kuulasmaa K, Kuusisto J, Laakso M, Lakka T, Langenberg C, Langsted A, Launer LJ, Lauritzen T, Liewald DCM, Lin LA, Linneberg A, Loos RJF, Lu Y, Lu X, Mägi R, Malarstig A, Manichaikul A, Manning AK, Mäntyselkä P, Marouli E, Masca NGD, Maschio A, Meigs JB, Melander O, Metspalu A, Morris AP, Morrison AC, Mulas A, Müller-Nurasyid M, Munroe PB, Neville MJ, Nielsen JB, Nielsen SF, Nordestgaard BG, Ordovas JM, Mehran R, O'Donnell CJ, Orho-Melander M, Molony CM, Muntendam P, Padmanabhan S, Palmer CNA, Pasko D, Patel AP, Pedersen O, Perola M, Peters A, Pisinger C, Pistis G, Polasek O, Poulter N, Psaty BM, Rader DJ, Rasheed A, Rauramaa R, Reilly DF, Reiner AP, Renström F, Rich SS, Ridker PM, Rioux JD, Robertson NR, Roden DM, Rotter JI, Rudan I, Salomaa V, Samani NJ, Sanna S, Sattar N, Schmidt EM, Scott RA, Sever P, Sevilla RS, Shaffer CM, Sim X, Sivapalaratnam S, Small KS, Smith AV, Smith BH, Somayajula S, Southam L, Spector TD, Speliotes EK, Starr JM, Stirrups KE, Stitziel N, Strauch K, Stringham HM, Surendran P, Tada H, Tall AR, Tang H, Tardif JC, Taylor KD, Trompet S, Tsao PS, Tuomilehto J, Tybjaerg-Hansen A, van Zuydam NR, Varbo A, Varga TV, Virtamo J, Waldenberger M, Wang N, Wareham NJ, Warren HR, Weeke PE, Weinstock J, Wessel J, Wilson JG, Wilson PWF, Xu M, Yaghootkar H, Young R, Zeggini E, Zhang H, Zheng NS, Zhang W, Zhang Y, Zhou W, Zhou Y, Zoledziewska M, Charge Diabetes Working Group, EPIC-InterAct Consortium, EPIC-CVD Consortium, GOLD Consortium, VA Million Veteran Program, Howson JMM, Danesh J, McCarthy MI, Cowan CA, Abecasis G, Deloukas P, Musunuru K, Willer CJ, Kathiresan S
  (2017) Nat Genet 49: 1758-1766
• The protein kinase IKKepsilon regulates energy balance in obese mice.
  Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR
  (2009) Cell 138: 961-75
• Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.
  Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK
  (2012) Cell 151: 138-52
• A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore.
  Krantz BA, Melnyk RA, Zhang S, Juris SJ, Lacy DB, Wu Z, Finkelstein A, Collier RJ
  (2005) Science 309: 777-81
• Control of pancreas and liver gene expression by HNF transcription factors.
  Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA
  (2004) Science 303: 1378-81
• Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver.
  Chaudhary AK, Nokubo M, Reddy GR, Yeola SN, Morrow JD, Blair IA, Marnett LJ
  (1994) Science 265: 1580-2
• Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.
  Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS
  (2009) Nat Med 15: 1383-91
• Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.
  Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF
  (2001) Nat Med 7: 699-705
• Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.
  An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB
  (2004) Nat Med 10: 268-74
• Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources.
  Stone MP, Cho YJ, Huang H, Kim HY, Kozekov ID, Kozekova A, Wang H, Minko IG, Lloyd RS, Harris TM, Rizzo CJ
  (2008) Acc Chem Res 41: 793-804
• Systems analysis of protein modification and cellular responses induced by electrophile stress.
  Jacobs AT, Marnett LJ
  (2010) Acc Chem Res 43: 673-83
• Free radical oxidation of polyunsaturated lipids: New mechanistic insights and the development of peroxyl radical clocks.
  Pratt DA, Tallman KA, Porter NA
  (2011) Acc Chem Res 44: 458-67
• SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
  Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC
  (2013) Mol Cell 50: 686-98
• Nonfatal acute myocardial infarction in Costa Rica: modifiable risk factors, population-attributable risks, and adherence to dietary guidelines.
  Kabagambe EK, Baylin A, Campos H
  (2007) Circulation 115: 1075-81
• Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study.
  Djoussé L, Arnett DK, Carr JJ, Eckfeldt JH, Hopkins PN, Province MA, Ellison RC, Investigators of the NHLBI FHS
  (2005) Circulation 111: 2921-6
• Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
  Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF
  (2007) Circulation 116: 1404-12
• Interplay between apolipoprotein E and scavenger receptor class B type I controls coronary atherosclerosis and lifespan in the mouse.
  Fazio S, Linton MF
  (2005) Circulation 111: 3349-51
• Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice.
  Burleigh ME, Babaev VR, Oates JA, Harris RC, Gautam S, Riendeau D, Marnett LJ, Morrow JD, Fazio S, Linton MF
  (2002) Circulation 105: 1816-23
• Molecular cues to implantation.
  Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T, Wang H
  (2004) Endocr Rev 25: 341-73
• Insights into G protein structure, function, and regulation.
  Cabrera-Vera TM, Vanhauwe J, Thomas TO, Medkova M, Preininger A, Mazzoni MR, Hamm HE
  (2003) Endocr Rev 24: 765-81
• Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.
  Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, Wongsiriroj N, Nagy HM, Ivanova PT, Scott SA, Knittelfelder O, Rechberger GN, Birner-Gruenberger R, Eder S, Brown HA, Haemmerle G, Oberer M, Lass A, Kershaw EE, Zimmermann R, Zechner R
  (2012) Cell Metab 15: 691-702
• Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25.
  Mullaney BC, Blind RD, Lemieux GA, Perez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA, Ashrafi K
  (2010) Cell Metab 12: 398-410