From the Director – David H. Wasserman, Ph.D.
The Vanderbilt MMPC was founded in 2001 to provide phenotyping services for mouse models of metabolic disease. The services are listed under the core to which they pertain. We work with scientists to optimize phenotyping tests. Please email me or one of the core directors for guidance regarding the strategy that will best serve your needs. Access our services by submitting a Request for Services (Order a Test). The MMPC also offers educational services highlighted by our annual class Glucose Clamping the Conscious Mouse. See the FAQ list or contact the Center Administrator Amanda Zetans for answers to a range of administrative questions.
The Analytical Resources, Metabolic Regulation, and Body Weight Regulation Cores provide novel techniques to better understand mouse models of diabetes and metabolic diseases. The Vanderbilt MMPC has access to state-of-the-art facilities for cardiovascular phenotyping through the independent Vanderbilt Cardiovascular Pathophysiology Core. In addition to these cores, there exists the Animal Health and Welfare Core, which performs husbandry and health assessments.
The development of transgenic technology and gene targeting protocols involving homologous recombination in embryonic stem cells has resulted in numerous mouse lines with specific phenotypes and well-defined DNA structural changes. Candidate genes for diabetes, obesity and other disorders of metabolism have been identified and transgenic mice have been generated using this technology. Moreover, mouse models with metabolic disorders have been created by large-scale mutagenesis. The mission is to advance research in the area of diabetes by providing novel experimental tools to the scientific community for phenotyping mouse transgenic models of diabetes and related disorders.
One index of success of the NIDDK MMPC program and the Vanderbilt MMPC specifically is the contribution of data produced by the MMPC to publications and oral communications. Please acknowledge the Vanderbilt MMPC when presenting data obtained using Center Services. The MMPC is supported in part by grant U24 DK059637.
Thank you for adherence to this policy.
Keywords: hormone, lipid, pathology, Core, assay, diabetes
Keywords: Energy Balance, bariatric surgery, telemetry
Keywords: pathophysiology, in vivo, metabolic, Core, imaging, training
Keywords: cardio complications, cardiovascular disease, cardio, Core, disease, blood pressure, complications, phenotypes, echo, telemetry, injury, myocardial
Keywords: animal health, Animal care, quarantine, receipt of mice, approved vendors, testing of mice, animal husbandry, Core, animal, vendors, testing, husbandry
If you send us mice from the approved animal vendor list below, your entire order can be handled within 6 weeks at a cost savings to you.
2017 Glucose Clamping the Conscious Mouse: A Laboratory Course
Mouse Metabolic Phenotyping Center - Vanderbilt University
September 11-15, 2017
Congratulations to Dr. Louise Lantier for receiving ADA Young Investigator Award!
Associate DirectorAmanda Zetans
MMPC Program Coordinator
The Vanderbilt Mouse Metabolic Phenotyping Center is supported by NIH grant U24 DK059637.
© 2009-2017 · Vanderbilt Mouse Metabolic Phenotyping Center, Vanderbilt
University Medical Center
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