Joel Harp
Last active: 7/24/2015

  1. Total synthesis of stemaphylline N-oxide and related C9a-epimeric analogues. Schulte ML, Turlington ML, Phatak SS, Harp JM, Stauffer SR, Lindsley CW (2013) Chemistry 19(36): 11847-52
    › Primary publication · 23956045 (PubMed) · PMC3925759 (PubMed Central)
  2. Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging. Tang D, McKinley ET, Hight MR, Uddin MI, Harp JM, Fu A, Nickels ML, Buck JR, Manning HC (2013) J Med Chem 56(8): 3429-33
    › Primary publication · 23521048 (PubMed) · PMC3648642 (PubMed Central)
  3. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375). Gentry PR, Kokubo M, Bridges TM, Kett NR, Harp JM, Cho HP, Smith E, Chase P, Hodder PS, Niswender CM, Daniels JS, Conn PJ, Wood MR, Lindsley CW (2013) J Med Chem 56(22): 9351-5
    › Primary publication · 24164599 (PubMed) · PMC3876027 (PubMed Central)
  4. Structure and function of YghU, a nu-class glutathione transferase related to YfcG from Escherichia coli. Stourman NV, Branch MC, Schaab MR, Harp JM, Ladner JE, Armstrong RN (2011) Biochemistry 50(7): 1274-81
    › Primary publication · 21222452 (PubMed) · PMC3040281 (PubMed Central)
  5. Computational design of an endo-1,4-beta-xylanase ligand binding site. Morin A, Kaufmann KW, Fortenberry C, Harp JM, Mizoue LS, Meiler J (2011) Protein Eng Des Sel 24(6): 503-16
    › Primary publication · 21349882 (PubMed) · PMC3092692 (PubMed Central)
  6. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. Duggan KC, Walters MJ, Musee J, Harp JM, Kiefer JR, Oates JA, Marnett LJ (2010) J Biol Chem 285(45): 34950-9
    › Primary publication · 20810665 (PubMed) · PMC2966109 (PubMed Central)
  7. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR (2010) J Biol Chem 285(3): 1773-80
    › Primary publication · 19923211 (PubMed) · PMC2804335 (PubMed Central)
  8. Analysis of the structure and function of YfcG from Escherichia coli reveals an efficient and unique disulfide bond reductase. Wadington MC, Ladner JE, Stourman NV, Harp JM, Armstrong RN (2009) Biochemistry 48(28): 6559-61
    › Primary publication · 19537707 (PubMed) · PMC2996727 (PubMed Central)
  9. Expedient placement of two fluorescent dyes for investigating dynamic DNA protein interactions in real time. Leuba SH, Anand SP, Harp JM, Khan SA (2008) Chromosome Res 16(3): 451-67
    › Primary publication · 18461484 (PubMed) · PMC2413326 (PubMed Central)
  10. Preparation and crystallization of nucleosome core particle. Hanson BL, Alexander C, Harp JM, Bunick GJ (2004) Methods Enzymol : 44-62
    › Primary publication · 14870658 (PubMed)