Brenda Leake
Last active: 7/29/2019

  1. In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. Cutler MJ, Urquhart BL, Velenosi TJ, Meyer Zu Schwabedissen HE, Dresser GK, Leake BF, Tirona RG, Kim RB, Freeman DJ (2012) J Clin Pharmacol 52(4): 530-42
    › Primary publication · 21505084 (PubMed)
  2. Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity. DeGorter MK, Ho RH, Leake BF, Tirona RG, Kim RB (2012) Mol Pharm 9(4): 986-95
    › Primary publication · 22352740 (PubMed) · PMC3319192 (PubMed Central)
  3. Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, George AL, Roden DM (2011) Circulation 124(9): 1001-11
    › Primary publication · 21824921 (PubMed) · PMC3297976 (PubMed Central)
  4. Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel. Atack TC, Stroud DM, Watanabe H, Yang T, Hall L, Hipkens SB, Lowe JS, Leake B, Magnuson MA, Yang P, Roden DM (2011) Circ Res 109(1): 38-46
    › Primary publication · 21566215 (PubMed) · PMC3135383 (PubMed Central)
  5. Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity. Schwarz UI, Meyer zu Schwabedissen HE, Tirona RG, Suzuki A, Leake BF, Mokrab Y, Mizuguchi K, Ho RH, Kim RB (2011) Pharmacogenet Genomics 21(3): 103-14
    › Primary publication · 21278621 (PubMed) · PMC3044558 (PubMed Central)
  6. Functional characterization of genetic variants in the apical sodium-dependent bile acid transporter (ASBT; SLC10A2). Ho RH, Leake BF, Urquhart BL, Gregor JC, Dawson PA, Kim RB (2011) J Gastroenterol Hepatol 26(12): 1740-8
    › Primary publication · 21649730 (PubMed) · PMC3170668 (PubMed Central)
  7. Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability. Ho RH, Leake BF, Kilkenny DM, Meyer Zu Schwabedissen HE, Glaeser H, Kroetz DL, Kim RB (2010) Pharmacogenet Genomics 20(1): 45-57
    › Primary publication · 20010382 (PubMed) · PMC2883163 (PubMed Central)
  8. Modulation of drug block of the cardiac potassium channel KCNA5 by the drug transporters OCTN1 and MDR1. Yang T, McBride BF, Leake BF, Kim RB, Roden DM (2010) Br J Pharmacol 161(5): 1023-33
    › Primary publication · 20977453 (PubMed) · PMC2998684 (PubMed Central)
  9. Human skeletal muscle drug transporters determine local exposure and toxicity of statins. Knauer MJ, Urquhart BL, Meyer zu Schwabedissen HE, Schwarz UI, Lemke CJ, Leake BF, Kim RB, Tirona RG (2010) Circ Res 106(2): 297-306
    › Primary publication · 19940267 (PubMed)
  10. Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe. Urquhart BL, Ware JA, Tirona RG, Ho RH, Leake BF, Schwarz UI, Zaher H, Palandra J, Gregor JC, Dresser GK, Kim RB (2008) Pharmacogenet Genomics 18(5): 439-48
    › Primary publication · 18408567 (PubMed) · PMC4043148 (PubMed Central)