NOTICE -- Login operations are currently offline due to an unscheduled disruption. We are waiting for LDAP services to be re-instated. We apologize for the inconvenience - June 24, 2021
Michael Waterman
Faculty Member
Last active: 2/12/2015

  1. Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2. Pallan PS, Nagy LD, Lei L, Gonzalez E, Kramlinger VM, Azumaya CM, Wawrzak Z, Waterman MR, Guengerich FP, Egli M (2015) J Biol Chem 290(6): 3248-68
    › Primary publication · 25533464 (PubMed) · PMC4318999 (PubMed Central)
  2. Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14α-demethylase: two regions of the enzyme molecule potentiate its inhibition. Friggeri L, Hargrove TY, Rachakonda G, Williams AD, Wawrzak Z, Di Santo R, De Vita D, Waterman MR, Tortorella S, Villalta F, Lepesheva GI (2014) J Med Chem 57(15): 6704-17
    › Primary publication · 25033013 (PubMed) · PMC4136671 (PubMed Central)
  3. VNI cures acute and chronic experimental Chagas disease. Villalta F, Dobish MC, Nde PN, Kleshchenko YY, Hargrove TY, Johnson CA, Waterman MR, Johnston JN, Lepesheva GI (2013) J Infect Dis 208(3): 504-11
    › Primary publication · 23372180 (PubMed) · PMC3698996 (PubMed Central)
  4. Unusual properties of the cytochrome P450 superfamily. Lamb DC, Waterman MR (2013) Philos Trans R Soc Lond B Biol Sci 368(1612): 20120434
    › Primary publication · 23297356 (PubMed) · PMC3538423 (PubMed Central)
  5. Streptomyces cytochromes P450: applications in drug metabolism. Lamb DC, Waterman MR, Zhao B (2013) Expert Opin Drug Metab Toxicol 9(10): 1279-94
    › Primary publication · 23738914 (PubMed)
  6. In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi. Soeiro Mde N, de Souza EM, da Silva CF, Batista Dda G, Batista MM, Pavão BP, Araújo JS, Aiub CA, da Silva PB, Lionel J, Britto C, Kim K, Sulikowski G, Hargrove TY, Waterman MR, Lepesheva GI (2013) Antimicrob Agents Chemother 57(9): 4151-63
    › Primary publication · 23774435 (PubMed) · PMC3754355 (PubMed Central)
  7. Cytochromes p450: roles in diseases. Pikuleva IA, Waterman MR (2013) J Biol Chem 288(24): 17091-8
    › Primary publication · 23632021 (PubMed) · PMC3682515 (PubMed Central)
  8. Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity. Hargrove TY, Wawrzak Z, Alexander PW, Chaplin JH, Keenan M, Charman SA, Perez CJ, Waterman MR, Chatelain E, Lepesheva GI (2013) J Biol Chem 288(44): 31602-15
    › Primary publication · 24047900 (PubMed) · PMC3814756 (PubMed Central)
  9. Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants. Zhao B, Lei L, Kagawa N, Sundaramoorthy M, Banerjee S, Nagy LD, Guengerich FP, Waterman MR (2012) J Biol Chem 287(13): 10613-10622
    › Primary publication · 22262854 (PubMed) · PMC3323056 (PubMed Central)
  10. The role of Ile87 of CYP158A2 in oxidative coupling reaction. Zhao B, Bellamine A, Lei L, Waterman MR (2012) Arch Biochem Biophys 518(2): 127-32
    › Primary publication · 22203090 (PubMed) · PMC3274592 (PubMed Central)