Alex Waterson
Faculty Member
Last active: 3/21/2014

  1. Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A. Frank AO, Vangamudi B, Feldkamp MD, Souza-Fagundes EM, Luzwick JW, Cortez D, Olejniczak ET, Waterson AG, Rossanese OW, Chazin WJ, Fesik SW (2014) J Med Chem 57(6): 2455-61
    › Primary publication · 24491171 (PubMed) · PMC3969094 (PubMed Central)
  2. Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Burns MC, Sun Q, Daniels RN, Camper D, Kennedy JP, Phan J, Olejniczak ET, Lee T, Waterson AG, Rossanese OW, Fesik SW (2014) Proc Natl Acad Sci U S A 111(9): 3401-6
    › Primary publication · 24550516 (PubMed) · PMC3948241 (PubMed Central)
  3. Surface reengineering of RPA70N enables cocrystallization with an inhibitor of the replication protein A interaction motif of ATR interacting protein. Feldkamp MD, Frank AO, Kennedy JP, Patrone JD, Vangamudi B, Waterson AG, Fesik SW, Chazin WJ (2013) Biochemistry 52(37): 6515-24
    › Primary publication · 23962067 (PubMed) · PMC3804075 (PubMed Central)
  4. Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. Patrone JD, Kennedy JP, Frank AO, Feldkamp MD, Vangamudi B, Pelz NF, Rossanese OW, Waterson AG, Chazin WJ, Fesik SW (2013) ACS Med Chem Lett 4(7): 601-605
    › Primary publication · 23914285 (PubMed) · PMC3728914 (PubMed Central)
  5. Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach. Frank AO, Feldkamp MD, Kennedy JP, Waterson AG, Pelz NF, Patrone JD, Vangamudi B, Camper DV, Rossanese OW, Chazin WJ, Fesik SW (2013) J Med Chem 56(22): 9242-50
    › Primary publication · 24147804 (PubMed) · PMC3932990 (PubMed Central)
  6. Structure-activity relationship of a broad-spectrum insect odorant receptor agonist. Taylor RW, Romaine IM, Liu C, Murthi P, Jones PL, Waterson AG, Sulikowski GA, Zwiebel LJ (2012) ACS Chem Biol 7(10): 1647-52
    › Primary publication · 22924767 (PubMed)
  7. Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Delpire E, Baranczak A, Waterson AG, Kim K, Kett N, Morrison RD, Daniels JS, Weaver CD, Lindsley CW (2012) Bioorg Med Chem Lett 22(14): 4532-5
    › Primary publication · 22727639 (PubMed) · PMC3389279 (PubMed Central)
  8. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Sun Q, Burke JP, Phan J, Burns MC, Olejniczak ET, Waterson AG, Lee T, Rossanese OW, Fesik SW (2012) Angew Chem Int Ed Engl 51(25): 6140-3
    › Primary publication · 22566140 (PubMed) · PMC3620661 (PubMed Central)
  9. Allosteric antagonism of insect odorant receptor ion channels. Jones PL, Pask GM, Romaine IM, Taylor RW, Reid PR, Waterson AG, Sulikowski GA, Zwiebel LJ (2012) PLoS One 7(1): e30304
    › Primary publication · 22272331 (PubMed) · PMC3260273 (PubMed Central)
  10. Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. Stoops SL, Pearson AS, Weaver C, Waterson AG, Days E, Farmer C, Brady S, Weaver CD, Beauchamp RD, Lindsley CW (2011) ACS Chem Biol 6(5): 452-65
    › Primary publication · 21241068 (PubMed) · PMC3401128 (PubMed Central)