Alan Brash
Last active: 3/22/2018

  1. Formation of a cyclopropyl epoxide via a leukotriene A synthase-related pathway in an anaerobic reaction of soybean lipoxygenase-1 with 15S-hydroperoxyeicosatetraenoic acid: evidence that oxygen access is a determinant of secondary reactions with fatty acid hydroperoxides. Zheng Y, Brash AR (2010) J Biol Chem 285(18): 13427-36
    › Primary publication · 20194505 (PubMed) · PMC2859502 (PubMed Central)
  2. Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids. Zheng Y, Brash AR (2010) J Biol Chem 285(51): 39866-75
    › Primary publication · 20921226 (PubMed) · PMC3000968 (PubMed Central)
  3. The structure and peroxidase activity of a 33-kDa catalase-related protein from Mycobacterium avium ssp. paratuberculosis. Pakhomova S, Gao B, Boeglin WE, Brash AR, Newcomer ME (2009) Protein Sci 18(12): 2559-68
    › Primary publication · 19827095 (PubMed) · PMC2821274 (PubMed Central)
  4. The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity. Neau DB, Gilbert NC, Bartlett SG, Boeglin W, Brash AR, Newcomer ME (2009) Biochemistry 48(33): 7906-15
    › Primary publication · 19594169 (PubMed) · PMC4715880 (PubMed Central)
  5. Mechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymes. Brash AR (2009) Phytochemistry 70(13-14): 1522-31
    › Primary publication · 19747698 (PubMed) · PMC2783490 (PubMed Central)
  6. Evidence for an ionic intermediate in the transformation of fatty acid hydroperoxide by a catalase-related allene oxide synthase from the Cyanobacterium Acaryochloris marina. Gao B, Boeglin WE, Zheng Y, Schneider C, Brash AR (2009) J Biol Chem 284(33): 22087-22098
    › Primary publication · 19531485 (PubMed) · PMC2755933 (PubMed Central)
  7. Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis. Niisuke K, Boeglin WE, Murray JJ, Schneider C, Brash AR (2009) J Lipid Res 50(7): 1448-55
    › Primary publication · 19244216 (PubMed) · PMC2694342 (PubMed Central)
  8. Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation. Schneider C, Porter NA, Brash AR (2008) J Biol Chem 283(23): 15539-43
    › Primary publication · 18285327 (PubMed) · PMC2414272 (PubMed Central)
  9. Role of the conserved distal heme asparagine of coral allene oxide synthase (Asn137) and human catalase (Asn148): mutations affect the rate but not the essential chemistry of the enzymatic transformations. Gao B, Boeglin WE, Brash AR (2008) Arch Biochem Biophys 477(2): 285-90
    › Primary publication · 18652800 (PubMed) · PMC2598388 (PubMed Central)
  10. Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases. Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, Brash AR (2008) Lipids 43(11): 979-87
    › Primary publication · 18795358 (PubMed) · PMC4710486 (PubMed Central)