Borden Lacy
Last active: 3/24/2020

  1. Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore. Anderson DM, Sheedlo MJ, Jensen JL, Lacy DB (2020) Nat Microbiol 5(1): 102-107
    › Primary publication · 31712627 (PubMed) · PMC6925320 (PubMed Central)
  2. Structural elucidation of the transferase toxin reveals a single-site binding mode for the enzyme. Sheedlo MJ, Anderson DM, Thomas AK, Lacy DB (2020) Proc Natl Acad Sci U S A 117(11): 6139-6144
    › Primary publication · 32123082 (PubMed) · PMC7084131 (PubMed Central)
  3. Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of TcdB-Induced Necrosis. Farrow MA, Chumber NM, Bloch SC, King M, Moton-Melancon K, Shupe J, Washington MK, Spiller BW, Lacy DB (2020) ACS Chem Biol 15(5): 1212-1221
    › Primary publication · 31909964 (PubMed) · PMC7230009 (PubMed Central)
  4. Intestinal bile acids directly modulate the structure and function of TcdB toxin. Tam J, Icho S, Utama E, Orrell KE, Gómez-Biagi RF, Theriot CM, Kroh HK, Rutherford SA, Lacy DB, Melnyk RA (2020) Proc Natl Acad Sci U S A 117(12): 6792-6800
    › Primary publication · 32152097 (PubMed) · PMC7104382 (PubMed Central)
  5. infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease. Mileto SJ, Jardé T, Childress KO, Jensen JL, Rogers AP, Kerr G, Hutton ML, Sheedlo MJ, Bloch SC, Shupe JA, Horvay K, Flores T, Engel R, Wilkins S, McMurrick PJ, Lacy DB, Abud HE, Lyras D (2020) Proc Natl Acad Sci U S A 117(14): 8064-8073
    › Primary publication · 32198200 (PubMed) · PMC7149309 (PubMed Central)
  6. Zinc intoxication induces ferroptosis in A549 human lung cells. Palmer LD, Jordan AT, Maloney KN, Farrow MA, Gutierrez DB, Gant-Branum R, Burns WJ, Romer CE, Tsui T, Allen JL, Beavers WN, Nei YW, Sherrod SD, Lacy DB, Norris JL, McLean JA, Caprioli RM, Skaar EP (2019) Metallomics 11(5): 982-993
    › Primary publication · 30968088 (PubMed) · PMC6531343 (PubMed Central)
  7. Structure of the Cag type IV secretion system. Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD (2019) Elife
    › Primary publication · 31210639 (PubMed) · PMC6620104 (PubMed Central)
  8. Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization. Su M, Erwin AL, Campbell AM, Pyburn TM, Salay LE, Hanks JL, Lacy DB, Akey DL, Cover TL, Ohi MD (2019) J Mol Biol 431(10): 1956-1965
    › Primary publication · 30954575 (PubMed) · PMC6625667 (PubMed Central)
  9. Control of antiviral innate immune response by protein geranylgeranylation. Yang S, Harding AT, Sweeney C, Miao D, Swan G, Zhou C, Jiang Z, Fitzgerald KA, Hammer G, Bergo MO, Kroh HK, Lacy DB, Sun C, Glogauer M, Que LG, Heaton NS, Wang D (2019) Sci Adv 5(5): eaav7999
    › Primary publication · 31149635 (PubMed) · PMC6541464 (PubMed Central)
  10. A neutralizing antibody that blocks delivery of the enzymatic cargo of toxin TcdB into host cells. Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB (2018) J Biol Chem 293(3): 941-952
    › Primary publication · 29180448 (PubMed) · PMC5777265 (PubMed Central)