H. Alex Brown
Principle Investigator; Professor of Pharmacology, Chemistry, and Biochemistry; Associate Director, VICB;
Last active: 2/12/2015

  1. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance. Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM (2015) Cell Rep 10(3): 326-338
    › Primary publication · 25600868 (PubMed) · PMC4501903 (PubMed Central)
  2. Human phospholipase D activity transiently regulates pyrimidine biosynthesis in malignant gliomas. Mathews TP, Hill S, Rose KL, Ivanova PT, Lindsley CW, Brown HA (2015) ACS Chem Biol 10(5): 1258-68
    › Primary publication · 25646564 (PubMed) · PMC4433586 (PubMed Central)
  3. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH, Russell DW, Subramaniam S, Brown HA (2015) J Lipid Res 56(3): 722-36
    › Primary publication · 25598080 (PubMed) · PMC4340319 (PubMed Central)
  4. Biochemical characterization of a Pseudomonas aeruginosa phospholipase D. Spencer C, Brown HA (2015) Biochemistry 54(5): 1208-18
    › Primary publication · 25565226 (PubMed) · PMC4337821 (PubMed Central)
  5. Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition. O'Reilly MC, Scott SA, Brown HA, Lindsley CW (2014) Bioorg Med Chem Lett 24(24): 5553-5557
    › Primary publication · 25466173 (PubMed) · PMC4535313 (PubMed Central)
  6. Chemical modulation of glycerolipid signaling and metabolic pathways. Scott SA, Mathews TP, Ivanova PT, Lindsley CW, Brown HA (2014) Biochim Biophys Acta 1841(8): 1060-84
    › Primary publication · 24440821 (PubMed) · PMC4069240 (PubMed Central)
  7. The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome. Thomas G, Betters JL, Lord CC, Brown AL, Marshall S, Ferguson D, Sawyer J, Davis MA, Melchior JT, Blume LC, Howlett AC, Ivanova PT, Milne SB, Myers DS, Mrak I, Leber V, Heier C, Taschler U, Blankman JL, Cravatt BF, Lee RG, Crooke RM, Graham MJ, Zimmermann R, Brown HA, Brown JM (2013) Cell Rep 5(2): 508-20
    › Primary publication · 24095738 (PubMed) · PMC3833083 (PubMed Central)
  8. Sum of the parts: mass spectrometry-based metabolomics. Milne SB, Mathews TP, Myers DS, Ivanova PT, Brown HA (2013) Biochemistry 52(22): 3829-40
    › Primary publication · 23442130 (PubMed) · PMC3674197 (PubMed Central)
  9. Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation. Scott SA, Xiang Y, Mathews TP, Cho HP, Myers DS, Armstrong MD, Tallman KA, O'Reilly MC, Lindsley CW, Brown HA (2013) J Biol Chem 288(28): 20477-87
    › Primary publication · 23723068 (PubMed) · PMC3711313 (PubMed Central)
  10. Multi-organ abnormalities and mTORC1 activation in zebrafish model of multiple acyl-CoA dehydrogenase deficiency. Kim SH, Scott SA, Bennett MJ, Carson RP, Fessel J, Brown HA, Ess KC (2013) PLoS Genet 9(6): e1003563
    › Primary publication · 23785301 (PubMed) · PMC3681725 (PubMed Central)