David Jacobson Ph.D - Publications

  1. Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity. Liu J, Banerjee A, Herring CA, Attalla J, Hu R, Xu Y, Shao Q, Simmons AJ, Dadi PK, Wang S, Jacobson DA, Liu B, Hodges E, Lau KS, Gu G (2019) Dev Cell 48(1): 49-63.e7
    › Primary publication · 30620902 (PubMed) · PMC6327977 (PubMed Central)
  2. Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion. Dickerson MT, Dadi PK, Altman MK, Verlage KR, Thorson AS, Jordan KL, Vierra NC, Amarnath G, Jacobson DA (2019) Am J Physiol Endocrinol Metab 316(4): E646-E659
    › Primary publication · 30694690 (PubMed) · PMC6482666 (PubMed Central)
  3. TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion. Vierra NC, Dickerson MT, Jordan KL, Dadi PK, Katdare KA, Altman MK, Milian SC, Jacobson DA (2018) Mol Metab : 84-97
    › Primary publication · 29402588 (PubMed) · PMC5870147 (PubMed Central)
  4. Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca Sensitivity of Insulin Secretion Vesicles. Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G (2018) Dev Cell 45(3): 347-361.e5
    › Primary publication · 29656931 (PubMed) · PMC5962294 (PubMed Central)
  5. Simultaneous Real-Time Measurement of the β-Cell Membrane Potential and Ca Influx to Assess the Role of Potassium Channels on β-Cell Function. Vierra NC, Dickerson MT, Philipson LH, Jacobson DA (2018) Methods Mol Biol : 73-84
    › Primary publication · 29058185 (PubMed) · PMC5927608 (PubMed Central)
  6. Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion. Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ (2018) Diabetes 67(2): 278-290
    › Primary publication · 29203512 (PubMed) · PMC5780059 (PubMed Central)
  7. Cytokine-mediated changes in K channel activity promotes an adaptive Ca response that sustains β-cell insulin secretion during inflammation. Dickerson MT, Bogart AM, Altman MK, Milian SC, Jordan KL, Dadi PK, Jacobson DA (2018) Sci Rep 8(1): 1158
    › Primary publication · 29348619 (PubMed) · PMC5773563 (PubMed Central)
  8. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC (2018) JCI Insight 3(8)
    › Primary publication · 29669939 (PubMed) · PMC5931120 (PubMed Central)
  9. Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes. Navarro G, Allard C, Morford JJ, Xu W, Liu S, Molinas AJ, Butcher SM, Fine NH, Blandino-Rosano M, Sure VN, Yu S, Zhang R, Münzberg H, Jacobson DA, Katakam PV, Hodson DJ, Bernal-Mizrachi E, Zsombok A, Mauvais-Jarvis F (2018) JCI Insight 3(12)
    › Primary publication · 29925687 (PubMed) · PMC6124401 (PubMed Central)
  10. β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions. Zhu L, Almaça J, Dadi PK, Hong H, Sakamoto W, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J (2017) Nat Commun : 14295
    › Primary publication · 28145434 (PubMed) · PMC5296650 (PubMed Central)