Douglas Mortlock
Assistant Professor of Molecular Physiology & Biop
Last active: 11/22/2019

Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.

Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E
Arterioscler Thromb Vasc Biol. 2014 34 (11): 2387-93

PMID: 25189570 · PMCID: PMC4199903 · DOI:10.1161/ATVBAHA.114.302523

Calcific aortic valve disease (CAVD) is increasingly prevalent worldwide with significant morbidity and mortality. Therapeutic options beyond surgical valve replacement are currently limited. In 2011, the National Heart Lung and Blood Institute assembled a working group on aortic stenosis. This group identified CAVD as an actively regulated disease process in need of further study. As a result, the Alliance of Investigators on CAVD was formed to coordinate and promote CAVD research, with the goals of identifying individuals at risk, developing new therapeutic approaches, and improving diagnostic methods. The group is composed of cardiologists, geneticists, imaging specialists, and basic science researchers. This report reviews the current status of CAVD research and treatment strategies with identification of areas in need of additional investigation for optimal management of this patient population.

© 2014 American Heart Association, Inc.

MeSH Terms (11)

Aortic Valve Aortic Valve Stenosis Biomedical Research Calcinosis Cardiac Surgical Procedures Heart Defects, Congenital Heart Valve Diseases Heart Valve Prosthesis Implantation Hemodynamics Humans Signal Transduction

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