Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.

Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA
Proc Natl Acad Sci U S A. 2005 102 (17): 6207-12

PMID: 15833818 · PMCID: PMC556131 · DOI:10.1073/pnas.0306743102

Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a crucial role in adipocyte differentiation, glucose metabolism, and other physiological processes. To further explore the role of PPARgamma in adipose tissues, we used a Cre/loxP strategy to generate adipose-specific PPARgamma knockout mice. These animals exhibited marked abnormalities in the formation and function of both brown and white adipose tissues. When fed a high-fat diet, adipose-specific PPARgamma knockout mice displayed diminished weight gain despite hyperphagia, had diminished serum concentrations of both leptin and adiponectin, and did not develop glucose intolerance or insulin resistance. Characterization of in vivo glucose dynamics pointed to improved hepatic glucose metabolism as the basis for preventing high-fat diet-induced insulin resistance. Our findings further illustrate the essential role for PPARgamma in the development of adipose tissues and suggest that a compensatory induction of hepatic PPARgamma may stimulate an increase in glucose disposal by the liver.

MeSH Terms (19)

Animals Blood Glucose Crosses, Genetic Dietary Fats Energy Intake Energy Metabolism Gene Deletion Glucose Tolerance Test Homeostasis Hyperinsulinism Insulin Resistance Lipid Metabolism Liver Mice Mice, Knockout Motor Activity Obesity PPAR gamma Triglycerides

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