Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.

Pino MF, Kim KA, Shelton KD, Lindner J, Odili S, Li C, Collins HW, Shiota M, Matschinsky FM, Magnuson MA
J Biol Chem. 2007 282 (18): 13906-16

PMID: 17353190 · DOI:10.1074/jbc.M610094200

MeSH Terms (21)

Adaptor Proteins, Signal Transducing Amino Acid Substitution Animals Blood Glucose Carrier Proteins Enzyme Activation Enzyme Stability Glucokinase Glucose Metabolism Disorders Hot Temperature Insulin Insulin Secretion Intracellular Signaling Peptides and Proteins Liver Mice Mice, Mutant Strains Mice, Transgenic Mutation, Missense Phenotype Protein Binding Recombinant Proteins

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