Alpha to Beta Cell Reprogramming: Stepping toward a New Treatment for Diabetes.

Osipovich AB, Magnuson MA
Cell Stem Cell. 2018 22 (1): 12-13

PMID: 29304337 · DOI:10.1016/j.stem.2017.12.012

Beta cell replacement strategies hold promise for permanently treating type 1 diabetes. In Cell Stem Cell, Xiao et al. (2018) restore pancreatic beta cell mass and normalize blood glucose in diabetic mice by reprogramming pancreatic alpha to beta cells using Pdx1- and Mafa-expressing adeno-associated virus infused into the pancreatic duct.

Copyright © 2017 Elsevier Inc. All rights reserved.

MeSH Terms (9)

Animals Cellular Reprogramming Diabetes Mellitus, Experimental Diabetes Mellitus, Type 1 Homeodomain Proteins Insulin Insulin-Secreting Cells Mice Pancreatic Ducts

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