Depression in patients with head and neck cancer and a functional genetic polymorphism of the serotonin transporter gene.

Gilbert J, Haman KL, Dietrich MS, Blakely RD, Shelton RC, Murphy BA
Head Neck. 2012 34 (3): 359-64

PMID: 21604315 · DOI:10.1002/hed.21744

BACKGROUND - Polymorphism of the serotonin transporter gene, 5-HTTLPR (short allele) has been associated with depression. The purpose of this study was to show the evaluated depression in patients with head and neck cancer and a possible association with the 5-HTTLPR.

METHODS - The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (SCID for DSM-IV) was administered to 94 patients with head and neck cancer, of which 33 patients were genotyped for 5-HTTLPR. We also evaluated the prevalence of 5-HTTLPR polymorphism in 121 patients with head and neck cancer and 97 controls.

RESULTS - Forty-three percent of the patients met the criteria for a depressive diagnosis, 19% of which was new onset. In depressed patients, 85.7% (n = 12 of 14) had at least 1 short allele versus 68.4% (n = 13 of 19) of the patients without depressive diagnosis (p < .04). No difference was noted in the prevalence of the short allele in head and neck cancer cases versus controls (odds ratio = 0.8; p = .490).

CONCLUSION - Despite the high rate of depressive diagnosis, patients with head and neck cancer did not demonstrate a higher prevalence of this short allele of the 5-HTTLPR compared with a control population.

Copyright © 2011 Wiley Periodicals, Inc.

MeSH Terms (15)

Adult Aged Aged, 80 and over Case-Control Studies Cohort Studies Depressive Disorder Female Head and Neck Neoplasms Humans Male Middle Aged Polymorphism, Genetic Prevalence Serotonin Plasma Membrane Transport Proteins Young Adult

Connections (3)

This publication is referenced by other Labnodes entities:

Links