Monoamine oxidase a promoter gene associated with problem behavior in adults with intellectual/developmental disabilities.

May ME, Srour A, Hedges LK, Lightfoot DA, Phillips JA, Blakely RD, Kennedy CH
Am J Intellect Dev Disabil. 2009 114 (4): 269-73

PMID: 19642709 · DOI:10.1352/1944-7558-114.4.269-273

A functional polymorphism in the promoter of the gene encoding monoamine oxidase A has been associated with problem behavior in various populations. We examined the association of MAOA alleles in adult males with intellectual/developmental disabilities with and without established histories of problem behavior. These data were compared with a gender, ethnicity, and age-matched contrast sample. About 43% (15/35) of adults with intellectual/developmental disabilities and problem behavior possessed the low-efficiency version of the MAOA gene. In comparison, 20% (7/35) of adults with intellectual/developmental disabilities and no problem behavior and 20% (7/35) of the contrast group had the short-allele MAOA polymorphism. Therefore, a common variant in the MAOA gene may be associated with problem behavior in adults with intellectual/developmental disabilities.

MeSH Terms (17)

Adolescent Adult Alleles Comorbidity Developmental Disabilities Female Genotype Humans Intellectual Disability Male Mental Disorders Middle Aged Minisatellite Repeats Monoamine Oxidase Polymorphism, Genetic Promoter Regions, Genetic Young Adult

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