High affinity inhibitors of the dopamine transporter (DAT): novel biotinylated ligands for conjugation to quantum dots.

Tomlinson ID, Mason JN, Blakely RD, Rosenthal SJ
Bioorg Med Chem Lett. 2006 16 (17): 4664-7

PMID: 16784853 · DOI:10.1016/j.bmcl.2006.05.097

Compounds capable of inhibiting the dopamine transporter protein (DAT) that can be conjugated to cadmium selenide/zinc sulfide/core shell nanocrystals may be used to image the location and distribution of the DAT in neuronal cell membranes. This letter describes the synthesis of biotinylated analogs of the DAT antagonists GBR 12909 and GBR 12935 that can be attached to streptavidin coated cadmium selenide/zinc sulfide/core shell nanocrystals.

MeSH Terms (8)

Biotinylation Dopamine Dopamine Plasma Membrane Transport Proteins Humans Inhibitory Concentration 50 Ligands Molecular Structure Quantum Dots

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