[Decrease in the platelet level of 43 kDa immunoreactive fraction of serotonin transporting protein correlates with depressive symptoms in patients with somatoform disorders].

Belous AR, Ramamoothy S, Blakely RD, Faktor MI, Lozier RKh, Dupin AM, Bechiashvili AG, Morozova MA, Brusov OS
Vopr Med Khim. 1999 45 (3): 256-62

PMID: 10432563

To elucidate the role of serotonin transporter (SERT) protein as a candidate target for somatoform disorders (SD), we have performed an association study of the SERT immunoreactive (IR-SERT) protein level by using site-specific antibodies directed at C-terminus epitope poorly conserved among other cotransporters. 22 patients who met DSM-IY criteria for SD and 32 healthy volunteers matched in sex and age participated in the study. In platelets from all healthy donors, IR-SERT proteins migrates as a diffuse band between 75 and 102 kDa and a major sharper band at 43 kDa. We revealed almost complete disappearance of platelet 43 kDa IR-SERT protein in all patients with SD. All patients were rated with Hamilton Depressive Rating Scale (HDRS). There were found a significant negative correlation between residual IR-SERT 43 kDa protein level and HDRS Scores [r = -0.83; P < 0.000001]. These findings suggest that a biosynthetic or processing abnormality may exist in SERTs in the affected population and may reflect the dysfunction of serotonin neurotransmission in CNS.

MeSH Terms (15)

Adult Blood Platelets Carrier Proteins Depression Female Humans Immunoblotting Male Membrane Glycoproteins Membrane Transport Proteins Middle Aged Nerve Tissue Proteins Serotonin Serotonin Plasma Membrane Transport Proteins Somatoform Disorders

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