Synthesis and characterization of a pegylated derivative of 3-(1,2,3,6-tetrahydro-pyridin-4yl)-1H-indole (IDT199): a high affinity SERT ligand for conjugation to quantum dots.

Tomlinson ID, Warnerment MR, Mason JN, Vergne MJ, Hercules DM, Blakely RD, Rosenthal SJ
Bioorg Med Chem Lett. 2007 17 (20): 5656-60

PMID: 17766114 · DOI:10.1016/j.bmcl.2007.07.061

Quantum dots consisting of a cadmium selenide core encapsulated in a shell of cadmium doped zinc sulfide have the potential to revolutionize fluorescent imaging of live cell cultures. In order to utilize these fluorescent probes it is necessary to functionalize them with biologically active ligands. In this paper we report the design and synthesis of a ligand that has a high affinity for the serotonin transporter (SERT) that may be conjugated to quantum dots.

MeSH Terms (8)

Indoles Inhibitory Concentration 50 Ligands Molecular Structure Polyethylene Glycols Quantum Dots Serotonin Plasma Membrane Transport Proteins Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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