Targeting the human serotonin transporter (hSERT) with quantum dots.

Tomlinson ID, Chang J, Iwamoto H, De Felice LJ, Blakely RD, Rosenthal SJ
Proc SPIE Int Soc Opt Eng. 2008 6866 (68660X): nihpa155701

PMID: 19936040 · PMCID: PMC2779040 · DOI:10.1117/12.782801

In this paper we report our work on the development of a human serotonin transporter (hSERT) antagonist that can be conjugated to quantum dots. This approach has been used to target and visualize the human serotonin transporter protein (hSERT). We demonstrate that labeling is blocked by the addition of high affinity hSERT antagonists such as paroxetine. This approach may be useful for the development of fluorescent assays to study the location and temporal dynamics of biogenic amine transporters and also holds promise for the development of plate-based high throughput assays used to identify novel transporter antagonists.

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