Leshana Saint-Jean
Clinical Trial Specialist
Last active: 2/18/2021

What chick and mouse models have taught us about the role of the endocardium in congenital heart disease.

DeLaughter DM, Saint-Jean L, Baldwin HS, Barnett JV
Birth Defects Res A Clin Mol Teratol. 2011 91 (6): 511-25

PMID: 21538818 · PMCID: PMC4824950 · DOI:10.1002/bdra.20809

Specific cell and tissue interactions drive the formation and function of the vertebrate cardiovascular system. Although much attention has been focused on the muscular components of the developing heart, the endocardium plays a key role in the formation of a functioning heart. Endocardial cells exhibit heterogeneity that allows them to participate in events such as the formation of the valves, septation of the outflow tract, and trabeculation. Here we review, the contributions of the endocardium to cardiovascular development and outline useful approaches developed in the chick and mouse that have revealed endocardial cell heterogeneity, the signaling molecules that direct endocardial cell behavior, and how these insights have contributed to our understanding of cardiovascular development and disease.

Copyright © 2011 Wiley-Liss, Inc.

MeSH Terms (8)

Animals Chick Embryo Disease Models, Animal Endocardium Gene Expression Regulation, Developmental Heart Defects, Congenital Mice Signal Transduction

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