Nellie Byun
Last active: 4/10/2019

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.

Gregory KJ, Herman EJ, Ramsey AJ, Hammond AS, Byun NE, Stauffer SR, Manka JT, Jadhav S, Bridges TM, Weaver CD, Niswender CM, Steckler T, Drinkenburg WH, Ahnaou A, Lavreysen H, Macdonald GJ, Bartolomé JM, Mackie C, Hrupka BJ, Caron MG, Daigle TL, Lindsley CW, Conn PJ, Jones CK
J Pharmacol Exp Ther. 2013 347 (2): 438-57

PMID: 23965381 · PMCID: PMC3807069 · DOI:10.1124/jpet.113.206623

MeSH Terms (22)

Allosteric Regulation Animals Antipsychotic Agents Dose-Response Relationship, Drug Drug Evaluation, Preclinical HEK293 Cells Humans Hyperkinesis Male Maze Learning Memory, Short-Term Mice Mice, Knockout Motor Activity Nootropic Agents Piperazines Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, N-Methyl-D-Aspartate Schizophrenia Transfection

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