Bethany Dale
graduate student
Last active: 9/7/2017

CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli.

Itani HA, Xiao L, Saleh MA, Wu J, Pilkinton MA, Dale BL, Barbaro NR, Foss JD, Kirabo A, Montaniel KR, Norlander AE, Chen W, Sato R, Navar LG, Mallal SA, Madhur MS, Bernstein KE, Harrison DG
Circ Res. 2016 118 (8): 1233-43

PMID: 26988069 · PMCID: PMC4833561 · DOI:10.1161/CIRCRESAHA.115.308111

Accumulating evidence supports a role of adaptive immunity and particularly T cells in the pathogenesis of hypertension. Formation of memory T cells, which requires the costimulatory molecule CD70 on antigen-presenting cells, is a cardinal feature of adaptive immunity.

MeSH Terms (13)

Animals Antigens, CD70 Blood Pressure Hypertension Inflammation Mediators Kidney Diseases Male Mice Mice, Inbred C57BL Mice, Knockout NG-Nitroarginine Methyl Ester Sodium Chloride, Dietary T-Lymphocytes

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