Ryan Hsi
Last active: 2/26/2019

Comparison of selective parenchymal clamping to hilar clamping during robotic-assisted laparoscopic partial nephrectomy.

Hsi RS, Macleod LC, Gore JL, Wright JL, Harper JD
Urology. 2014 83 (2): 339-44

PMID: 24246321 · PMCID: PMC4843515 · DOI:10.1016/j.urology.2013.09.033

OBJECTIVE - To compare perioperative outcomes after robotic-assisted laparoscopic partial nephrectomy (RALPN) with hilar clamping vs parenchymal clamping.

METHODS - A retrospective, single-institution review of the patients undergoing RALPN with hilar or parenchymal clamping was performed. Associations between perioperative factors and clinicopathologic outcomes were determined using the t test, Fisher's exact test, and multivariate linear regression.

RESULTS - In 51 patients undergoing RALPN, 36 (71%) and 15 (29%) were performed with hilar and parenchymal clamping, respectively. Median tumor diameter was 2.8 cm for both groups (range, 1.1-6.1; P = .93). Tumor complexity by nephrometry score was mild (69% vs 80%), moderate (29% vs 20%), and high (2% vs 0%) in the respective groups (P = .65). Operative time was significantly shorter in the parenchymal clamp group (median 245 vs 320 minutes; P <.0001). There was no difference in blood loss and need for transfusion. On multivariate analysis, hilar clamping (P <.01), higher body mass index (P = .01), and higher complexity tumors (P = .02) were significantly associated with longer operative times. The parenchymal clamp group had better preservation of immediate postoperative glomerular filtration rate (GFR) from baseline to postoperative day 2 (median ΔGFR 0 vs -18 mL/min/1.73 m(2), P = .02). These differences from baseline did not persist (median ΔGFR -6 vs -7 mL/min/1.73 m(2), P = .35) at a median follow-up of 6.6 months. Final pathology determination of malignancy (P = .51) and positive margin rates (P = .26) were similar in both groups.

CONCLUSION - Compared with hilar clamping, selective regional ischemia with the parenchymal clamp for mild-moderately complex tumors is feasible and safe during RALPN. Parenchymal clamping is associated with enhanced immediate preservation of GFR and shorter operative times.

Copyright © 2014 Elsevier Inc. All rights reserved.

MeSH Terms (13)

Adult Aged Aged, 80 and over Constriction Female Humans Laparoscopy Male Middle Aged Nephrectomy Retrospective Studies Robotics Young Adult

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