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William Holmes
Last active: 2/26/2016

Interactions and tradeoffs between cell recruitment, proliferation, and differentiation affect CNS regeneration.

Holmes WR, Nie Q
Biophys J. 2014 106 (7): 1528-36

PMID: 24703314 · PMCID: PMC3976526 · DOI:10.1016/j.bpj.2014.02.010

Regeneration of central nervous system (CNS) lesions requires movement of progenitor cells and production of their differentiated progeny. Although damage to the CNS clearly promotes these two processes, the interplay between these complex events and how it affects a response remains elusive. Here, we use spatial stochastic modeling to show that tradeoffs arise between production and recruitment during regeneration. Proper spatial control of cell cycle timing can mitigate these tradeoffs, maximizing recruitment, improving infiltration into the lesion, and reducing wasteful production outside of it. Feedback regulation of cell lineage dynamics alone however leads to spatial defects in cell recruitment, suggesting a novel, to our knowledge, hypothesis for the aggregation of cells to the periphery of a lesion in multiple sclerosis. Interestingly, stronger chemotaxis does not correct this aggregation and instead, substantial random cell motions near the site of the lesion are required to improve CNS regeneration.

Copyright © 2014 Biophysical Society. Published by Elsevier Inc. All rights reserved.

MeSH Terms (17)

Animals Cell Aggregation Cell Cycle Cell Differentiation Cell Movement Cell Proliferation Central Nervous System Chemotaxis Computer Simulation Feedback, Physiological Mice Models, Neurological Multiple Sclerosis Nerve Regeneration Neurogenesis Stochastic Processes Time Factors

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