W. Rathmell
Last active: 8/8/2016

A tale of two cancers: Complete genetic analysis of chromophobe renal cell carcinoma contrasts with clear cell renal cell carcinoma.

Fahey CC, Rathmell WK
Mol Cell Oncol. 2015 2 (2): e979686

PMID: 27308442 · PMCID: PMC4904899 · DOI:10.4161/23723556.2014.979686

The Cancer Genome Atlas undertook a comprehensive genetic analysis of chromophobe renal cell carcinoma, the first of the rare tumor types to be analyzed. This analysis identified the putative region of origin as the distal nephron. Alterations in mitochondrial function, mtDNA mutations, and recurrent structural rearrangements within the TERT promoter region were also identified.

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