W. Rathmell
Last active: 8/8/2016

HIF transcription factor expression and induction of hypoxic response genes in a retroperitoneal angiosarcoma.

Rathmell WK, Acs G, Simon MC, Vaughn DJ
Anticancer Res. 2004 24 (1): 167-9

PMID: 15015593

Angiosarcoma is a rare and highly aggressive tumor of endothelial origin. The molecular mechanisms driving angiosarcoma growth have not been fully elucidated, although autocrine stimulation by vascular endothelial growth factor (VEGF) secretion may play a role in the pathogenesis of this tumor. We identified a patient with a very rare form of angiosarcoma arising from the retroperitoneum. Immunohistochemical analysis demonstrated widespread up-regulation of the hypoxic response pathway as a mechanism of enhanced VEGF expression. Disordered regulation of the hypoxic response pathway can result in the expression of factors such as VEGF and erythropoietin, which may promote autocrine tumor growth in angiosarcoma.

MeSH Terms (10)

Basic Helix-Loop-Helix Transcription Factors Gene Expression Regulation, Neoplastic Hemangiosarcoma Humans Hypoxia-Inducible Factor 1, alpha Subunit Male Middle Aged Retroperitoneal Neoplasms Trans-Activators Transcription Factors

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