Ming Jiang
Last active: 7/6/2016

PPARγ: a molecular link between systemic metabolic disease and benign prostate hyperplasia.

Jiang M, Strand DW, Franco OE, Clark PE, Hayward SW
Differentiation. 2011 82 (4-5): 220-36

PMID: 21645960 · PMCID: PMC3174339 · DOI:10.1016/j.diff.2011.05.008

The emergent epidemic of metabolic syndrome and its complex list of sequelae mandate a more thorough understanding of benign prostatic hyperplasia and lower urinary tract symptoms (BPH/LUTS) in the context of systemic metabolic disease. Here we discuss the nature and origins of BPH, examine its role as a component of LUTS and review retrospective clinical studies that have drawn associations between BPH/LUTS and type II diabetes, inflammation and dyslipidemia. PPARγ signaling, which sits at the nexus of systemic metabolic disease and BPH/LUTS through its regulation of inflammation and insulin resistance, is proposed as a candidate for molecular manipulation in regard to BPH/LUTS. Finally, we introduce new cell and animal models that are being used to study the consequences of obesity, diabetes and inflammation on benign prostatic growth.

Copyright © 2011 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

MeSH Terms (14)

Animals Diabetes Mellitus, Type 2 Disease Models, Animal Dyslipidemias Humans Inflammation Lower Urinary Tract Symptoms Male Mice Molecular Targeted Therapy PPAR gamma Prostate Prostatic Hyperplasia Signal Transduction

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