Ming Jiang
Last active: 7/6/2016

p53 independent G1 arrest and apoptosis induced by adriamycin.

Shao Z, Jiang M, Yu L, Han Q, Shen Z
Chin Med Sci J. 1997 12 (2): 71-5

PMID: 11324502

The biological activity of adriamycin was investigated in human breast carcinoma (HBC) cells, Adriamycin inhibited the growth of a number of HBC cell lines and induced G1 arrest followed by apoptosis. In MCF-7 cells that harbor wild-type p53, adriamycin-induced G1 arrest and apoptosis was accompanied by p53-independent regulation of WAF1/CIP1 as well as bax mRNA levels. In MDA-MB-231 cells which possess a mutant p53, adriamycin-induced G1 arrest and apoptosis was also associated with a concomitant up-regulation of WAF1/CIP1 mRNA while these cells did not express bax or bcl-2 messages. Thus, adriamycin induces G1 arrest and apoptosis via a unique pathway which appears to involve activation of downstream effectors of p53-independent manner.

MeSH Terms (14)

Antineoplastic Agents Apoptosis Breast Neoplasms Cell Division Cyclin-Dependent Kinase Inhibitor p21 Cyclins Doxorubicin Female G1 Phase Genes, p53 Humans Mutation RNA, Messenger Tumor Cells, Cultured

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