Joel Harp
Last active: 7/24/2015

Total synthesis of stemaphylline N-oxide and related C9a-epimeric analogues.

Schulte ML, Turlington ML, Phatak SS, Harp JM, Stauffer SR, Lindsley CW
Chemistry. 2013 19 (36): 11847-52

PMID: 23956045 · PMCID: PMC3925759 · DOI:10.1002/chem.201302669

Winning the relay: The first total synthesis of stemaphylline N-oxide has been completed utilizing a bistandem relay ring-closing-metathesis (RRCM) strategy, necessitated by the conformation of the requisite tetraene. This effort also gave unnatural 9a-epi-stemaphylline and 9a-epi-stemaphylline N-oxide.

Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.

MeSH Terms (4)

Alkaloids Alkenes Cyclization Molecular Conformation

Connections (1)

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