Robert Matthews
Last active: 3/10/2016

Effects of fencamfamine on single unit activity of mesencephalic dopaminergic neurons in rats.

Matthews RT
J Neural Transm. 1988 71 (1): 45-55

PMID: 3343595

Systemic fencamfamine (0.5-16 mg/kg, i.v.) significantly but incompletely inhibited spontaneous activity of nigrostriatal and mesolimbic/mesocortical dopamine (DA) neurons. Inhibition was reversed by haloperidol (0.1 mg/kg, i.v.) and prevented by pretreatment with alpha-methyltyrosine (50 mg/kg, i.v.) plus reserpine (5 mg/kg, i.p.). Pretreatment with alpha-methyltyrosine alone attenuated inhibition at high but not low doses of fencamfamine. Microiontophoresed fencamfamine had little direct effect on DA neurons and did not consistently modulate the effects of co-microiontophoresed DA. In contrast, systemic fencamfamine blocked the inhibitory effects of low doses of apomorphine (10-40 micrograms/kg, i.v.). Fencamfamine appears to be an indirect DA agonist which interacts with both vesicular and newly synthesized DA storage pools. Fencamfamine may also cause a rapid desensitization to the effects of DA autoreceptor stimulation.

MeSH Terms (16)

Action Potentials alpha-Methyltyrosine Animals Dopamine Dose-Response Relationship, Drug Drug Interactions Haloperidol Injections, Intravenous Iontophoresis Male Mesencephalon Methyltyrosines Norbornanes Rats Rats, Inbred Strains Reserpine

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