Gerald Stubbs
Last active: 2/15/2016

Structure of microtubules with reduced hydration. Comparison of results from X-ray diffraction and electron microscopy.

Beese L, Stubbs G, Thomas J, Cohen C
J Mol Biol. 1987 196 (3): 575-80

PMID: 3681968 · DOI:10.1016/0022-2836(87)90033-7

A recent model for the structure of microtubules is used to interpret X-ray fiber diffraction patterns from microtubules, obtained under various conditions. The results suggest that tubulin may undergo conformational changes under conditions of reduced water-activity. Such changes could account for some of the differences in the structure of tubulin as determined by electron microscopy and X-ray diffraction.

MeSH Terms (6)

Microscopy, Electron Microtubules Models, Biological Protein Conformation Tubulin X-Ray Diffraction

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