Jennifer Noto
Last active: 11/30/2018

Helicobacter pylori Makes a Molecular Incision to Gain Epithelial Entry.

Noto JM, Peek RM
Cell Host Microbe. 2017 22 (4): 434-436

PMID: 29024639 · PMCID: PMC5656741 · DOI:10.1016/j.chom.2017.09.014

Helicobacter pylori type IV secretion system injects the oncoprotein CagA into epithelial cells to drive carcinogenesis. In this issue of Cell Host & Microbe, Tegtmeyer et al. (2017) show that a secreted bacterial protease disrupts apical-junctional complexes, paving the way for H. pylori to access the basolateral compartment and trigger pathogenesis.

Copyright © 2017 Elsevier Inc. All rights reserved.

MeSH Terms (7)

Antigens, Bacterial Bacterial Proteins Epithelial Cells Helicobacter Infections Helicobacter pylori Humans Oncogene Proteins

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