Jennifer Noto
Last active: 11/30/2018

The Mongolian Gerbil: A Robust Model of Helicobacter pylori-Induced Gastric Inflammation and Cancer.

Noto JM, Romero-Gallo J, Piazuelo MB, Peek RM
Methods Mol Biol. 2016 1422: 263-80

PMID: 27246040 · PMCID: PMC5915618 · DOI:10.1007/978-1-4939-3603-8_24

The Mongolian gerbil is an efficient, robust, and cost-effective rodent model that recapitulates many features of H. pylori-induced gastric inflammation and carcinogenesis in humans, allowing for targeted investigation of the bacterial determinants and environmental factors and, to a lesser degree, host constituents that govern H. pylori-mediated disease. This chapter discusses means through which the Mongolian gerbil model has been used to define mechanisms of H. pylori-inflammation and cancer as well as the current materials and methods for utilizing this model of microbially induced disease.

MeSH Terms (8)

Animals Disease Models, Animal Gerbillinae Helicobacter Infections Helicobacter pylori Humans Risk Factors Stomach Neoplasms

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