Jennifer Noto
Last active: 11/30/2018

Micronutrients: A double-edged sword in microbial-induced gastric carcinogenesis.

Noto JM, Peek RM
Trends Cancer. 2015 1 (2): 136-144

PMID: 26623443 · PMCID: PMC4662415 · DOI:10.1016/j.trecan.2015.07.002

Epidemiologic studies throughout the world have uniformly demonstrated significant relationships between the intake of dietary micronutrients and gastric cancer risk. An exciting concept that has gained considerable traction recently is that micronutrients modulate gene expression within , the strongest identified risk factor for gastric carcinogenesis. We present evidence here that essential micronutrients have a direct effect on virulence, which subsequently affects interactions at the host-pathogen interface, thereby facilitating the development of premalignant and malignant lesions in the stomach. Further, these fundamental concepts provide a framework for understanding mechanisms driving the development of other malignancies that arise from foci of gastrointestinal inflammation.

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