Jennifer Noto
Last active: 11/30/2018

Microbial Regulation of p53 Tumor Suppressor.

Zaika AI, Wei J, Noto JM, Peek RM
PLoS Pathog. 2015 11 (9): e1005099

PMID: 26379246 · PMCID: PMC4574736 · DOI:10.1371/journal.ppat.1005099

p53 tumor suppressor has been identified as a protein interacting with the large T antigen produced by simian vacuolating virus 40 (SV40). Subsequent research on p53 inhibition by SV40 and other tumor viruses has not only helped to gain a better understanding of viral biology, but also shaped our knowledge of human tumorigenesis. Recent studies have found, however, that inhibition of p53 is not strictly in the realm of viruses. Some bacterial pathogens also actively inhibit p53 protein and induce its degradation, resulting in alteration of cellular stress responses. This phenomenon was initially characterized in gastric epithelial cells infected with Helicobacter pylori, a bacterial pathogen that commonly infects the human stomach and is strongly linked to gastric cancer. Besides H. pylori, a number of other bacterial species were recently discovered to inhibit p53. These findings provide novel insights into host-bacteria interactions and tumorigenesis associated with bacterial infections.

MeSH Terms (11)

Animals Bacterial Physiological Phenomena Carcinogenesis Host-Pathogen Interactions Humans Immunity, Innate Infection Neoplasms Stress, Physiological Tumor Suppressor Protein p53 Virus Physiological Phenomena

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