Jennifer Noto
Last active: 11/30/2018

Regulation of Helicobacter pylori Virulence Within the Context of Iron Deficiency.

Noto JM, Lee JY, Gaddy JA, Cover TL, Amieva MR, Peek RM
J Infect Dis. 2015 211 (11): 1790-4

PMID: 25505301 · PMCID: PMC4447831 · DOI:10.1093/infdis/jiu805

Helicobacter pylori strains that harbor the oncoprotein CagA increase gastric cancer risk, and this risk is augmented under iron-deficient conditions. We demonstrate here that iron depletion induces coccoid morphology in strains lacking cagA. To evaluate the stability of augmented H. pylori virulence phenotypes stimulated by low-iron conditions, H. pylori isolated from iron-depleted conditions in vivo were serially passaged in vitro. Long-term passage decreased the ability of hypervirulent strains to translocate CagA or induce interleukin 8, indicating that hypervirulent phenotypes stimulated by low-level iron conditions are reversible. Therefore, rectifying iron deficiency may attenuate disease among H. pylori-infected persons with no response to antibiotics.

© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

MeSH Terms (11)

Animals Antigens, Bacterial Bacterial Proteins Gene Knockout Techniques Gerbillinae Helicobacter Infections Helicobacter pylori Interleukin-8 Iron Stomach Virulence

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