Karen Joos
Last active: 4/3/2019

Half corneal light shield as a delivery system for standardized application of mitomycin C.

Khoury JM, Joos KM, Shen JH, Davis D, O'Day DM
J Glaucoma. 1998 7 (1): 8-11

PMID: 9493108

PURPOSE - The authors develop a simple and economical method of applying reproducible intraoperative doses of mitomycin C for glaucoma filtering surgery.

METHODS - A three-part protocol was developed to study several properties of half corneal light shields (HCLSs). Part A tested the amount of mitomycin C (0.4 mg/ml) absorbed, the expansion dimensions attained, and the amount released to filter paper. In part B, the in vitro release of mitomycin C to an enucleated pig eye was examined. In part C, the in vivo release during intraoperative filtering surgery was tested.

RESULTS - The amount of mitomycin C solution absorbed by the HCLSs ranged from 1.07 x 10(-2) mg to 1.19 x 10(-2) mg; expansion width ranged from 6.8 mm to 7.0 mm; expansion height ranged from 3.6 mm to 3.8 mm; expansion thickness was constant at 0.6 mm. The amount of solution released to filter paper ranged from 6.8 x 10(-3) mg to 8.6 x 10(-3) mg. The amount of solution transferred to the pig eye ranged from 1.0 x 10(-3) mg to 2.7 x 10(-3) mg. The amount of solution released in filtering surgery ranged from 2.0 x 10(-3) mg to 4.8 x 10(-3) mg.

CONCLUSIONS - The contact surface area, the amount absorbed, and the amount released by each HCLS was reproducible. The uniform thickness theoretically provides a uniform distribution of mitomycin C. This method may allow standardization of intraoperative mitomycin C application, and may reduce the incidence of complications.

MeSH Terms (12)

Absorption Animals Antibiotics, Antineoplastic Cornea Drug Delivery Systems Filtering Surgery Glaucoma Humans Intraoperative Period Mitomycin Reproducibility of Results Swine

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