Karen Joos
Last active: 4/3/2019

Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography.

Malone JD, El-Haddad MT, Bozic I, Tye LA, Majeau L, Godbout N, Rollins AM, Boudoux C, Joos KM, Patel SN, Tao YK
Biomed Opt Express. 2017 8 (1): 193-206

PMID: 28101411 · PMCID: PMC5231292 · DOI:10.1364/BOE.8.000193

Scanning laser ophthalmoscopy (SLO) benefits diagnostic imaging and therapeutic guidance by allowing for high-speed imaging of retinal structures. When combined with optical coherence tomography (OCT), SLO enables real-time aiming and retinal tracking and provides complementary information for post-acquisition volumetric co-registration, bulk motion compensation, and averaging. However, multimodality SLO-OCT systems generally require dedicated light sources, scanners, relay optics, detectors, and additional digitization and synchronization electronics, which increase system complexity. Here, we present a multimodal ophthalmic imaging system using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography (SS-SESLO-OCT) for human retinal imaging. SESLO reduces the complexity of imaging systems by multiplexing spatial positions as a function of wavelength. SESLO image quality benefited from single-mode illumination and multimode collection through a prototype double-clad fiber coupler, which optimized scattered light throughput and reduce speckle contrast while maintaining lateral resolution. Using a shared 1060 nm swept-source, shared scanner and imaging optics, and a shared dual-channel high-speed digitizer, we acquired inherently co-registered retinal images and OCT cross-sections simultaneously at 200 frames-per-second.

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