Carlos Grijalva
Last active: 7/27/2018

Community-Acquired Pneumonia Hospitalization among Children with Neurologic Disorders.

Millman AJ, Finelli L, Bramley AM, Peacock G, Williams DJ, Arnold SR, Grijalva CG, Anderson EJ, McCullers JA, Ampofo K, Pavia AT, Edwards KM, Jain S
J Pediatr. 2016 173: 188-195.e4

PMID: 27017483 · PMCID: PMC4897771 · DOI:10.1016/j.jpeds.2016.02.049

OBJECTIVE - To describe and compare the clinical characteristics, outcomes, and etiology of pneumonia among children hospitalized with community-acquired pneumonia (CAP) with neurologic disorders, non-neurologic underlying conditions, and no underlying conditions.

STUDY DESIGN - Children <18 years old hospitalized with clinical and radiographic CAP were enrolled at 3 US children's hospitals. Neurologic disorders included cerebral palsy, developmental delay, Down syndrome, epilepsy, non-Down syndrome chromosomal abnormalities, and spinal cord abnormalities. We compared the epidemiology, etiology, and clinical outcomes of CAP in children with neurologic disorders with those with non-neurologic underlying conditions, and those with no underlying conditions using bivariate, age-stratified, and multivariate logistic regression analyses.

RESULTS - From January 2010-June 2012, 2358 children with radiographically confirmed CAP were enrolled; 280 (11.9%) had a neurologic disorder (52.1% of these individuals also had non-neurologic underlying conditions), 934 (39.6%) had non-neurologic underlying conditions only, and 1144 (48.5%) had no underlying conditions. Children with neurologic disorders were older and more likely to require intensive care unit (ICU) admission than children with non-neurologic underlying conditions and children with no underlying conditions; similar proportions were mechanically ventilated. In age-stratified analysis, children with neurologic disorders were less likely to have a pathogen detected than children with non-neurologic underlying conditions. In multivariate analysis, having a neurologic disorder was associated with ICU admission for children ≥2 years of age.

CONCLUSIONS - Children with neurologic disorders hospitalized with CAP were less likely to have a pathogen detected and more likely to be admitted to the ICU than children without neurologic disorders.

Published by Elsevier Inc.

MeSH Terms (21)

Adolescent Case-Control Studies Cerebral Palsy Child Child, Preschool Chromosome Aberrations Community-Acquired Infections Developmental Disabilities Down Syndrome Epilepsy Female Hospitalization Humans Intensive Care Units Length of Stay Male Patient Admission Pneumonia Spinal Cord Tennessee Utah

Connections (1)

This publication is referenced by other Labnodes entities:

Links