Carlos Grijalva
Last active: 7/27/2018

Estimating age-specific influenza-related hospitalization rates during the pandemic (H1N1) 2009 in Davidson Co, TN.

Jules A, Grijalva CG, Zhu Y, Talbot KH, Williams JV, Dupont WD, Edwards KM, Schaffner W, Shay DK, Griffin MR
Influenza Other Respir Viruses. 2012 6 (3): e63-71

PMID: 22360812 · PMCID: PMC3773818 · DOI:10.1111/j.1750-2659.2012.00343.x

BACKGROUND - In April 2009, a pandemic caused by a novel influenza strain, the A(H1N1)pdm09 virus, started. Few age-specific estimates of hospitalizations associated with the first year of circulation of the pandemic virus are available.

OBJECTIVES - To estimate age-specific hospitalization rates associated with laboratory-confirmed A(H1N1)pdm09 virus in Davidson County, TN, from May 2009 to March 2010.

PATIENTS/METHODS - Two separate strategies were applied: capture-recapture and surveillance-sampling methods. For the capture-recapture estimates, we linked data collected via two independent prospective population-based surveillance systems: The Influenza Vaccine Effectiveness Network (Flu-VE) tested consenting county patients hospitalized with respiratory symptoms at selected hospitals using real-time reverse transcriptase polymerase chain reaction (rRT-PCR); the Emerging Infections Program identified county patients with positive influenza tests in all area hospitals. For the surveillance-sampling estimates, we applied the age-specific proportions of influenza-positive patients (from Flu-VE) to the number of acute respiratory illness hospitalizations obtained from the Tennessee Hospital Discharge Data system.

RESULTS - With capture-recapture, we estimated 0·89 (95% CI, 0·72-1·49), 0·62 (0·42-1·11), 1·78 (0·99-3·63), and 0·76 (0·50-1·76) hospitalizations per 1000 residents aged < 5, 5-17, 18-49, and ≥ 50 years, respectively. Surveillance-sampling estimated rates were 0·78 (0·46-1·22), 0·32 (0·14-0·69), 0·99 (0·64-1·52), and 1·43 (0·80-2·48) hospitalizations per 1000 residents aged <5, 5-17, 18-49, and ≥ 50 years, respectively. In all age-groups combined, we estimated approximately 1 influenza-related hospitalization per 1000 residents.

CONCLUSIONS - Two independent methods provided consistent results on the burden of pandemic virus in Davidson County and suggested that the overall incidence of A(H1N1)pdm09-associated hospitalization was 1 per 1000 county residents.

© 2012 Blackwell Publishing Ltd.

MeSH Terms (17)

Adolescent Adult Age Factors Child Child, Preschool Female Hospitalization Humans Influenza, Human Influenza A Virus, H1N1 Subtype Influenza Vaccines Male Middle Aged Pandemics Prospective Studies Tennessee Young Adult

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