Carlos Grijalva
Last active: 7/27/2018

Trends in antibiotic prescribing for adults in the United States--1995 to 2002.

Roumie CL, Halasa NB, Grijalva CG, Edwards KM, Zhu Y, Dittus RS, Griffin MR
J Gen Intern Med. 2005 20 (8): 697-702

PMID: 16050877 · PMCID: PMC1490171 · DOI:10.1111/j.1525-1497.2005.0148.x

CONTEXT - The impact of national efforts to limit antibiotic prescribing has not been fully evaluated.

OBJECTIVES - To analyze trends in outpatient visits associated with antibiotic prescription for U.S. adults.

DESIGN - Cross-sectional study of data (1995 to 2002) from the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey.

PARTICIPANTS - Adults > or =18 years with an outpatient visit to an office- or hospital-based medical practice or to an emergency department. All visits were classified into 1 of 4 diagnostic categories: (1) acute respiratory infection (ARI)-antibiotics rarely indicated, (2) ARI-antibiotics often indicated, (3) nonrespiratory infection-antibiotics often indicated, and (4) all others.

MEASUREMENTS - Trends in: (1) Proportion of outpatient visits associated with an antibiotic prescription; (2) proportion of antibiotic prescriptions that were broad spectrum; and (3) number of visits and antibiotic prescriptions per 1,000 U.S. adults > or =18 years of age.

RESULTS - From 1995-1996 to 2001-2002, the proportion of all outpatient visits that generated an antibiotic prescription decreased from 17.9% to 15.3% (adjusted odds ratio [OR] 0.84, 95 % confidence interval [CI] 0.76 to 0.92). The entire reduction was because of a decrease in antibiotic prescriptions associated with visits for ARIs where antibiotics are rarely indicated from 59.9% to 49.1% (adjusted OR 0.64 95% CI 0.51 to 0.80). However, the proportion of prescribed antibiotics for these visits that were classified as broad-spectrum antibiotic prescription increased from 41.0% to 76.8%. Overall outpatient visits increased from 1693 to 1986 per 1,000 adults over the 8 years studied, but associated antibiotic prescriptions changed little, from 302 to 304 per 1,000 adults.

CONCLUSION - During the study period, outpatient antibiotic prescribing for respiratory infections where antibiotics are rarely indicated has declined, while the proportion of broad-spectrum antibiotics prescribed for these diagnoses has increased significantly. This trend resulted in a 15% decline in the total proportion of outpatient visits in which antibiotics were prescribed. However, because outpatient visits increased 17% over this time period, the population burden of outpatient antibiotic prescriptions changed little.

MeSH Terms (11)

Adult Ambulatory Care Anti-Bacterial Agents Cross-Sectional Studies Drug Utilization Humans Logistic Models Odds Ratio Practice Patterns, Physicians' Respiratory Tract Infections United States

Connections (2)

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