Jane Ferguson
Last active: 3/3/2020

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment: A Scientific Statement From the American Heart Association.

Ferguson JF, Allayee H, Gerszten RE, Ideraabdullah F, Kris-Etherton PM, Ordovás JM, Rimm EB, Wang TJ, Bennett BJ, American Heart Association Council on Functional Genomics and Translational Biology, Council on Epidemiology and Prevention, and Stroke Council
Circ Cardiovasc Genet. 2016 9 (3): 291-313

PMID: 27095829 · PMCID: PMC7829062 · DOI:10.1161/HCG.0000000000000030

Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple "omic" measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome. Here, we describe the current state of the field of nutrigenomics with respect to cardiometabolic disease research and outline a direction for the integration of multiple omics techniques in future nutrigenomic studies aimed at understanding mechanisms and developing new therapeutic options for cardiometabolic disease treatment and prevention.

© 2016 American Heart Association, Inc.

MeSH Terms (24)

American Heart Association Animals Biomedical Research Cardiovascular Diseases Diet Diffusion of Innovation Epigenesis, Genetic Forecasting Gastrointestinal Microbiome Gastrointestinal Tract Gene-Environment Interaction Genetic Predisposition to Disease Genetic Variation Host-Pathogen Interactions Humans Metagenomics Nutrigenomics Nutritional Status Nutrition Assessment Phenotype Preventive Health Services Risk Assessment Risk Factors United States

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