Dulek DE, Williams JV, Creech CB, Schulert AK, Frangoul HA, Domm J, Denison MR, Chappell JD
Clin Infect Dis. 2010 50 (11)
Immunosuppressed patients receiving oseltamivir for 2009 novel H1N1 influenza A infection may develop drug resistance, leading to treatment failure. Intravenous zanamivir was administered on a compassionate-use basis to a profoundly immunosuppressed pediatric patient with severe oseltamivir-resistant novel H1N1 pneumonia. The regimen was well tolerated and was associated with a decrease in viral burden.
MeSH Terms (15)Antiviral Agents Compassionate Use Trials Critical Illness Drug Resistance, Viral Female Humans Immunocompromised Host Infant Influenza, Human Influenza A Virus, H1N1 Subtype Injections, Intravenous Oseltamivir Treatment Outcome Viral Load Zanamivir